About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Wnt5a
wingless-type MMTV integration site family, member 5A
MGI:98958

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wnt5a. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 27, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Allgeier SH et al. (2008) WNT5A selectively inhibits mouse ventral prostate development. Dev Biol, 324:10-7. (PubMed:18804104)
  2. Andersson ER et al. (2009) Genetic interaction between Lrp6 and Wnt5a during mouse development. Dev Dyn, 239:237-245. (PubMed:19795512)
  3. Andersson ER et al. (2008) Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS ONE, 3:e3517. (PubMed:18953410)
  4. Austin TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood, 89:3624-35. (PubMed:9160667)
  5. Banyai L et al. (2012) Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1. FEBS Lett, 586:3122-6. (PubMed:22986341)
  6. Bilkovski R et al. (2010) Role of WNT-5a in the determination of human mesenchymal stem cells into preadipocytes. J Biol Chem, 285:6170-8. (PubMed:20032469)
  7. Blakely BD et al. (2011) Wnt5a regulates midbrain dopaminergic axon growth and guidance. PLoS One, 6:e18373. (PubMed:21483795)
  8. Blumenthal A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood, 108:965-73. (PubMed:16601243)
  9. Bryja V et al. (2009) The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell, 20:924-36. (PubMed:19056682)
  10. Cervantes S et al. (2009) Wnt5a is essential for intestinal elongation in mice. Dev Biol, 326:285-94. (PubMed:19100728)
  11. Cha KB et al. (2004) WNT5A signaling affects pituitary gland shape. Mech Dev, 121:183-94. (PubMed:15037319)
  12. Davis EK et al. (2008) Wnts acting through canonical and noncanonical signaling pathways exert opposite effects on hippocampal synapse formation. Neural Dev, 3:32. (PubMed:18986540)
  13. Fu J et al. (2009) Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A, 106:18598-603. (PubMed:19841259)
  14. Gazit A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene, 18:5959-66. (PubMed:10557084)
  15. Gonzalez-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol, 24:4757-68. (PubMed:15143170)
  16. He X et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science, 275:1652-4. (PubMed:9054360)
  17. Ishikawa T et al. (2001) Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development, 128:25-33. (PubMed:11092808)
  18. Keeble TR et al. (2006) The Wnt receptor Ryk is required for Wnt5a-mediated axon guidance on the contralateral side of the corpus callosum. J Neurosci, 26:5840-8. (PubMed:16723543)
  19. Kim HJ et al. (2005) Wnt5 signaling in vertebrate pancreas development. BMC Biol, 3:23. (PubMed:16246260)
  20. Li C et al. (2002) Wnt5a participates in distal lung morphogenesis. Dev Biol, 248:68-81. (PubMed:12142021)
  21. Liang H et al. (2007) Noncanonical Wnt signaling promotes apoptosis in thymocyte development. J Exp Med, 204:3077-84. (PubMed:18070933)
  22. Liu H et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science, 317:803-6. (PubMed:17690294)
  23. Liu W et al. (2008) Coordinated molecular control of otic capsule differentiation: functional role of Wnt5a signaling and opposition by sfrp3 activity. Growth Factors, 26:343-54. (PubMed:18991062)
  24. Matsuyama M et al. (2009) Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet, 5:e1000427. (PubMed:19300477)
  25. Mericskay M et al. (2004) Wnt5a is required for proper epithelial-mesenchymal interactions in the uterus. Development, 131:2061-72. (PubMed:15073149)
  26. Mikels AJ et al. (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol, 4:e115. (PubMed:16602827)
  27. Naillat F et al. (2010) Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet, 19:1539-50. (PubMed:20106871)
  28. Oishi I et al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells, 8:645-54. (PubMed:12839624)
  29. Pereira C et al. (2008) Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10. Arterioscler Thromb Vasc Biol, 28:504-10. (PubMed:18174455)
  30. Pino D et al. (2011) Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro, 3:e00059. (PubMed:21539518)
  31. Potok MA et al. (2008) WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth. Dev Dyn, 237:1006-20. (PubMed:18351662)
  32. Qian D et al. (2007) Wnt5a functions in planar cell polarity regulation in mice. Dev Biol, 306:121-33. (PubMed:17433286)
  33. Roarty K et al. (2007) Wnt5a is required for proper mammary gland development and TGF-{beta}-mediated inhibition of ductal growth. Development, 134:3929-39. (PubMed:17898001)
  34. Sato A et al. (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J, 29:41-54. (PubMed:19910923)
  35. Smolich BD et al. (1993) Wnt Family Proteins Are Secreted and Associated with the Cell Surface Mol Biol Cell, 4:1267-1275. (PubMed:8167409)
  36. Takada R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells, 10:919-28. (PubMed:16115200)
  37. Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem, 267:4300-11. (PubMed:10866835)
  38. Topol L et al. (2003) Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation. J Cell Biol, 162:899-908. (PubMed:12952940)
  39. Toyofuku T et al. (2000) Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J Cell Biol, 150:225-41. (PubMed:10893270)
  40. Verkaar F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell Signal, 21:22-33. (PubMed:18929644)
  41. Warr N et al. (2009) Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev Biol, 326:273-84. (PubMed:19100252)
  42. Wawrzak D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun, 357:1119-23. (PubMed:17462603)
  43. Welsh IC et al. (2013) Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell, 26:629-44. (PubMed:24091014)
  44. Yamaguchi TP et al. (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development, 126:1211-23. (PubMed:10021340)
  45. Yamamoto H et al. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells, 12:1215-23. (PubMed:17986005)
  46. Yamamoto S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell, 15:23-36. (PubMed:18606138)
  47. Zaghetto AA et al. (2007) Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci, 27:9757-68. (PubMed:17804636)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory