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Gene Ontology Classifications
wingless-type MMTV integration site family, member 3A

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wnt3a. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Alfieri CM et al. (2010) Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol, 338:127-35. (PubMed:19961844)
  2. Aulehla A et al. (2003) Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell, 4:395-406. (PubMed:12636920)
  3. Banyai L et al. (2012) Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1. FEBS Lett, 586:3122-6. (PubMed:22986341)
  4. Bayle J et al. (2008) Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol, 128:871-81. (PubMed:17943183)
  5. Bilic J et al. (2007) Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science, 316:1619-22. (PubMed:17569865)
  6. Brack AS et al. (2009) BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration. Dev Biol, 335:93-105. (PubMed:19699733)
  7. Chu EY et al. (2004) Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development, 131:4819-29. (PubMed:15342465)
  8. Cohen ED et al. (2009) Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest, 119:2538-49. (PubMed:19690384)
  9. Fan CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev Biol, 191:160-5. (PubMed:9356179)
  10. Gazit A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene, 18:5959-66. (PubMed:10557084)
  11. Gonzalez-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol, 24:4757-68. (PubMed:15143170)
  12. Gruneberg H et al. (1974) A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch). J Embryol Exp Morphol, 31:207-22. (PubMed:4819561)
  13. Hay E et al. (2009) N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation. Mol Cell Biol, 29:953-64. (PubMed:19075000)
  14. Holmen SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem, 277:34727-35. (PubMed:12121999)
  15. Kanazawa A et al. (2005) Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun, 330:505-10. (PubMed:15796911)
  16. Kawai M et al. (2007) Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem Biophys Res Commun, 363:276-82. (PubMed:17888405)
  17. Kim M et al. (2010) Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt. FEBS Lett, 584:3923-8. (PubMed:20804755)
  18. Le Grand F et al. (2009) Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell, 4:535-47. (PubMed:19497282)
  19. Lee JS et al. (1999) Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway. J Biol Chem, 274:21464-70. (PubMed:10409711)
  20. Lee SM et al. (2000) A local Wnt-3a signal is required for development of the mammalian hippocampus. Development, 127:457-67. (PubMed:10631167)
  21. Liu G et al. (2003) A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol Cell Biol, 23:5825-35. (PubMed:12897152)
  22. Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A, 104:3859-64. (PubMed:17360443)
  23. Lu W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell, 119:97-108. (PubMed:15454084)
  24. Luo W et al. (2005) Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions. J Biol Chem, 280:5054-60. (PubMed:15579909)
  25. Lyons JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp Cell Res, 298:369-87. (PubMed:15265686)
  26. Mikels AJ et al. (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol, 4:e115. (PubMed:16602827)
  27. Mirotsou M et al. (2007) Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci U S A, 104:1643-8. (PubMed:17251350)
  28. Muroyama Y et al. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev, 16:548-53. (PubMed:11877374)
  29. Nakaya MA et al. (2005) Wnt3alinks left-right determination with segmentation and anteroposterior axis elongation. Development, 132:5425-36. (PubMed:16291790)
  30. Nam JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem, 281:13247-57. (PubMed:16543246)
  31. Oderup C et al. (2013) Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance. J Immunol, 190:6126-34. (PubMed:23677472)
  32. Olkku A et al. (2008) Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells. Bone, 43:483-93. (PubMed:18555765)
  33. Ouji Y et al. (2008) Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem Biophys Res Commun, 367:299-304. (PubMed:18155657)
  34. Paik JH et al. (2009) FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell, 5:540-53. (PubMed:19896444)
  35. Pino D et al. (2011) Wnt5a controls neurite development in olfactory bulb interneurons. ASN Neuro, 3:e00059. (PubMed:21539518)
  36. Pinson KI et al. (2000) An LDL-receptor-related protein mediates Wnt signalling in mice Nature, 407:535-8. (PubMed:11029008)
  37. Purro SA et al. (2008) Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli. J Neurosci, 28:8644-54. (PubMed:18716223)
  38. Reya T et al. (2003) A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 423:409-14. (PubMed:12717450)
  39. Reya T et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity, 13:15-24. (PubMed:10933391)
  40. Riccomagno MM et al. (2005) Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev, 19:1612-23. (PubMed:15961523)
  41. Rios-Esteves J et al. (2014) Identification of key residues and regions important for porcupine-mediated Wnt acylation. J Biol Chem, 289:17009-19. (PubMed:24798332)
  42. Sato A et al. (2010) Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J, 29:41-54. (PubMed:19910923)
  43. Satoh K et al. (2004) Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci U S A, 101:8017-21. (PubMed:15148409)
  44. Schinner S et al. (2008) Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia, 51:147-54. (PubMed:17994217)
  45. Schwarz-Romond T et al. (2007) Dynamic recruitment of axin by Dishevelled protein assemblies. J Cell Sci, 120:2402-12. (PubMed:17606995)
  46. Si W et al. (2006) CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol, 26:2955-64. (PubMed:16581771)
  47. Smolich BD et al. (1993) Wnt Family Proteins Are Secreted and Associated with the Cell Surface Mol Biol Cell, 4:1267-1275. (PubMed:8167409)
  48. Steele BM et al. (2009) Canonical Wnt signaling negatively regulates platelet function. Proc Natl Acad Sci U S A, 106:19836-41. (PubMed:19901330)
  49. Suriben R et al. (2009) Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak. Nat Genet, 41:977-85. (PubMed:19701191)
  50. Takada R et al. (2005) Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation. Genes Cells, 10:919-28. (PubMed:16115200)
  51. Takada S et al. (1994) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev, 8:174-89. (PubMed:8299937)
  52. Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem, 267:4300-11. (PubMed:10866835)
  53. Toyofuku T et al. (2000) Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex. J Cell Biol, 150:225-41. (PubMed:10893270)
  54. Verkaar F et al. (2009) Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells. Cell Signal, 21:22-33. (PubMed:18929644)
  55. Viti J et al. (2003) Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2. J Neurosci, 23:5919-27. (PubMed:12843296)
  56. Wawrzak D et al. (2007) Wnt3a binds to several sFRPs in the nanomolar range. Biochem Biophys Res Commun, 357:1119-23. (PubMed:17462603)
  57. Yamamoto S et al. (2008) Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev Cell, 15:23-36. (PubMed:18606138)
  58. Yasuda S et al. (2011) AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells. Biochem J, 437:345-55. (PubMed:21554246)
  59. Yokoyama N et al. (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J Cell Sci, 122:4439-51. (PubMed:19920076)
  60. Yoshikawa Y et al. (1997) Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol, 183:234-42. (PubMed:9126297)
  61. Zhang X et al. (2012) Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell, 149:1565-77. (PubMed:22726442)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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