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Gene Ontology Classifications
Symbol
Name
ID
Wnt1
wingless-type MMTV integration site family, member 1
MGI:98953

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Wnt1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Adachi S et al. (2004) Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res, 64:8496-501. (PubMed:15574752)
  2. Austin TW et al. (1997) A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood, 89:3624-35. (PubMed:9160667)
  3. Bafico A et al. (1998) Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene, 16:2819-25. (PubMed:9652750)
  4. Bally-Cuif L et al. (1995) Involvement of Wnt-1 in the formation of the mes/metencephalic boundary. Mech Dev, 53:23-34. (PubMed:8555108)
  5. Bennett CN et al. (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A, 102:3324-9. (PubMed:15728361)
  6. Brennan K et al. (2004) Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins. Oncogene, 23:4873-84. (PubMed:15064719)
  7. Capdevila J et al. (1998) Control of dorsoventral somite patterning by Wnt-1 and beta-catenin. Dev Biol, 193:182-94. (PubMed:9473323)
  8. Carroll TJ et al. (2005) Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell, 9:283-92. (PubMed:16054034)
  9. Carter M et al. (2005) Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. Proc Natl Acad Sci U S A, 102:12843-8. (PubMed:16126904)
  10. Dassule HR et al. (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol, 202:215-27. (PubMed:9769173)
  11. Fan CM et al. (1997) A role for WNT proteins in induction of dermomyotome. Dev Biol, 191:160-5. (PubMed:9356179)
  12. Finch PW et al. (1997) Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A, 94:6770-5. (PubMed:9192640)
  13. Fu J et al. (2009) Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation. Proc Natl Acad Sci U S A, 106:18598-603. (PubMed:19841259)
  14. Gazit A et al. (1999) Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene, 18:5959-66. (PubMed:10557084)
  15. Gonzalez-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol, 24:4757-68. (PubMed:15143170)
  16. Holmen SL et al. (2002) A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem, 277:34727-35. (PubMed:12121999)
  17. Johnson EB et al. (2005) Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice. Hum Mol Genet, 14:3523-38. (PubMed:16207730)
  18. Kato M et al. (2002) Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol, 157:303-14. (PubMed:11956231)
  19. Lavado A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development, 135:441-50. (PubMed:18094027)
  20. Liu H et al. (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science, 317:803-6. (PubMed:17690294)
  21. Liu W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J, 25:1646-58. (PubMed:16601693)
  22. Lu W et al. (2004) Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell, 119:97-108. (PubMed:15454084)
  23. Lyons JP et al. (2004) Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells. Exp Cell Res, 298:369-87. (PubMed:15265686)
  24. McMahon AP et al. (1990) The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell, 62:1073-85. (PubMed:2205396)
  25. McMahon AP et al. (1989) int-1--a proto-oncogene involved in cell signalling. Development, 107 Suppl:161-7. (PubMed:2534596)
  26. Muroyama Y et al. (2002) Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev, 16:548-53. (PubMed:11877374)
  27. Nam JS et al. (2006) Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression. J Biol Chem, 281:13247-57. (PubMed:16543246)
  28. Ohira T et al. (2003) WNT7a induces E-cadherin in lung cancer cells. Proc Natl Acad Sci U S A, 100:10429-34. (PubMed:12937339)
  29. Prakash N et al. (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development, 133:89-98. (PubMed:16339193)
  30. Riccomagno MM et al. (2005) Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev, 19:1612-23. (PubMed:15961523)
  31. Rochat A et al. (2004) Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol Biol Cell, 15:4544-55. (PubMed:15282335)
  32. Ross SE et al. (2000) Inhibition of adipogenesis by Wnt signaling. Science, 289:950-3. (PubMed:10937998)
  33. Schryver B et al. (1996) Properties of Wnt-1 protein that enable cell surface association. Oncogene, 13:333-42. (PubMed:8710372)
  34. Semenov MV et al. (2001) Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol, 11:951-61. (PubMed:11448771)
  35. Staal FJ et al. (2001) Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription. Eur J Immunol, 31:285-93. (PubMed:11265645)
  36. Tamai K et al. (2000) LDL-receptor-related proteins in Wnt signal transduction. Nature, 407:530-5. (PubMed:11029007)
  37. Tanaka K et al. (2000) The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem, 267:4300-11. (PubMed:10866835)
  38. Thomas KR et al. (1990) Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development. Nature, 346:847-50. (PubMed:2202907)
  39. Xu Q et al. (2004) Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell, 116:883-95. (PubMed:15035989)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory