Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vwf. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 25, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Vwf
  • is located in the following cellular components:
    • external side of plasma membrane ^[1]
• The gene product of Vwf has been shown to bind to the gene products of Mfap2. ^[8]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Vwf
  • participates in the following biological processes:
    • blood coagulation ^{[3, 4, 5]}
    • cell-substrate adhesion ^[2]
    • hemostasis ^[4]
    • liver development ^[7]
    • placenta development ^[7]
    • platelet activation ^{[3, 6]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vwf:
  • participates in the following biological processes:
    • blood coagulation
    • cell adhesion
    • cell-substrate adhesion
    • hemostasis
    • platelet activation
    • protein homooligomerization
  • performs the following molecular functions:
    • chaperone binding
    • collagen binding
    • glycoprotein binding
    • immunoglobulin binding
    • integrin binding
    • protease binding
    • protein homodimerization activity
    • protein N-terminus binding
  • is located in the following cellular components:
    • endoplasmic reticulum
    • extracellular matrix
    • extracellular region
    • Weibel-Palade body

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Summary text based on GO annotations supported by structural data

• Vwf encodes a protein or proteins that contain the following InterPro domains: Cystine knot, Cystine knot, C-terminal, Trypsin Inhibitor-like, cysteine rich domain, Uncharacterised domain, cysteine-rich, von Willebrand factor, von Willebrand factor, type A, von Willebrand factor, type C, von Willebrand factor, type D domain, indicating that the gene product:
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vwf indicates that it:
  • is located in the following cellular components:
    • proteinaceous extracellular matrix

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References

1. Aigner S et al. (1995) Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin. Int Immunol, 7:1557-65. (PubMed:8562500)
2. Andre P et al. (2000) Platelets adhere to and translocate on von willebrand factor presented by endothelium in stimulated veins Blood, 96:3322-8. (PubMed:11071623)
3. Cosemans JM et al. (2011) Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow. Blood, 117:651-60. (PubMed:21037087)
4. Denis C et al. (1998) A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci U S A, 95:9524-9. (PubMed:9689113)
5. Dubois C et al. (2007) Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest, 117:953-60. (PubMed:17380206)
6. Ni H et al. (2000) Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. J Clin Invest, 106:385-92. (PubMed:10930441)
7. Schmidt C et al. (1995) Scatter factor/hepatocyte growth factor is essential for liver development. Nature, 373:699-702. (PubMed:7854452)
8. Werneck CC et al. (2008) Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood, 111:4137-44. (PubMed:18281502)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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