Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vldlr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Vldlr
  • is located in the following cellular components:
    • extracellular space ^[4]
• The gene product of Vldlr has been shown to bind to the gene products of Dab1. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Vldlr
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Vldlr
  • participates in the following biological processes:
    • positive regulation of dendrite development based on interactions with Lrp8 ^[2]
    • positive regulation of protein kinase activity based on interactions with Lrp8, Reln ^[1]
    • reelin-mediated signaling pathway based on interactions with Lrp8 ^[2]
  • performs the following molecular functions:
    • reelin receptor activity based on interactions with Lrp8 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Vldlr:
  • participates in the following biological processes:
    • cellular response to hypoxia
    • glycoprotein transport
    • receptor-mediated endocytosis
    • very-low-density lipoprotein particle clearance
  • performs the following molecular functions:
    • apolipoprotein binding
    • calcium-dependent protein binding
    • glycoprotein binding
    • glycoprotein transporter activity
    • very-low-density lipoprotein particle binding
    • very-low-density lipoprotein particle receptor activity
  • is located in the following cellular components:
    • apical part of cell
    • cell surface
    • membrane
    • nucleus
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Vldlr encodes a protein or proteins that contain the following InterPro domains: EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Growth factor, receptor, LDLR class B repeat, Low-density lipoprotein (LDL) receptor class A repeat, Low-density lipoprotein (LDL) receptor class A, conserved site, Six-bladed beta-propeller, TolB-like, indicating that the gene product:
  • performs the following molecular functions:
    • calcium ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Vldlr indicates that it:
  • participates in the following biological processes:
    • cholesterol metabolic process
    • endocytosis
    • lipid metabolic process
    • lipid transport
    • steroid metabolic process
    • transport
  • is located in the following cellular components:
    • coated pit
    • integral to membrane
    • very-low-density lipoprotein particle

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References

1. Bock HH et al. (2003) Reelin activates SRC family tyrosine kinases in neurons. Curr Biol, 13:18-26. (PubMed:12526740)
2. Fish KN et al. (2008) Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol Dis, 32:391-401. (PubMed:18778775)
3. Herrick TM et al. (2004) High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res, 126:121-8. (PubMed:15249135)
4. Hoe HS et al. (2005) Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res, 137:31-9. (PubMed:15950758)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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