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Gene Ontology Classifications
Symbol
Name
ID
Vim
vimentin
MGI:98932

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Vim. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
References
  1. . () , :. (PubMed:)
  2. Eiraku M et al. (2005) DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci, 8:873-80. (PubMed:15965470)
  3. Engle LJ et al. (1994) Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene. Genomics, 19:407-16. (PubMed:8188282)
  4. Gimenez Y Ribotta M et al. (2000) Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia, 31:69-83. (PubMed:10816608)
  5. Goto H et al. (2002) Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Genes Cells, 7:91-7. (PubMed:11895474)
  6. Greene SB et al. (2010) A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci, 123:606-18. (PubMed:20103531)
  7. Ha BK et al. (2000) Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat, 19:129-41. (PubMed:10989258)
  8. Jing R et al. (2007) Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci, 120:1267-77. (PubMed:17356066)
  9. Keuschnigg J et al. (2009) The prototype endothelial marker PAL-E is a leukocyte trafficking molecule. Blood, 114:478-84. (PubMed:19420356)
  10. Ma Z et al. (2006) Interaction between ROCK II and nucleophosmin/B23 in the regulation of centrosome duplication. Mol Cell Biol, 26:9016-34. (PubMed:17015463)
  11. Menet V et al. (2001) Inactivation of the glial fibrillary acidic protein gene, but not that of vimentin, improves neuronal survival and neurite growth by modifying adhesion molecule expression. J Neurosci, 21:6147-58. (PubMed:11487638)
  12. Monteiro MJ et al. (1989) Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. J Cell Biol, 108:579-93. (PubMed:2493000)
  13. Nery FC et al. (2008) TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J Cell Sci, 121:3476-86. (PubMed:18827015)
  14. Sandilands A et al. (2004) Bfsp2 mutation found in mouse 129 strains causes the loss of CP49' and induces vimentin-dependent changes in the lens fibre cell cytoskeleton. Exp Eye Res, 78:875-89. (PubMed:15037121)
  15. Schlafli P et al. (2011) Substrate preference and phosphatidylinositol monophosphate inhibition of the catalytic domain of the Per-Arnt-Sim domain kinase PASKIN. FEBS J, 278:1757-68. (PubMed:21418524)
  16. Seandel M et al. (2007) Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature, 449:346-50. (PubMed:17882221)
  17. Takemura M et al. (2002) Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci, 22:6972-9. (PubMed:12177195)
  18. Tao H et al. (2005) A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development, 132:3217-30. (PubMed:15958512)
  19. van den Heuvel AP et al. (2002) Binding of protein kinase B to the plakin family member periplakin. J Cell Sci, 115:3957-66. (PubMed:12244133)
  20. Wyatt K et al. (2008) A role for lengsin, a recruited enzyme, in terminal differentiation in the vertebrate lens. J Biol Chem, 283:6607-15. (PubMed:18178558)
  21. Yang P et al. (2005) A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS. J Comp Neurol, 490:163-79. (PubMed:16052496)
  22. Yoon KH et al. (2009) Periplakin interactions with lens intermediate and beaded filaments. Invest Ophthalmol Vis Sci, 50:1283-9. (PubMed:19029034)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory