Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Scgb1a1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Scgb1a1
  • participates in the following biological processes:
    • negative regulation of interferon-gamma production ^[1]
    • negative regulation of interleukin-13 production ^[1]
    • negative regulation of interleukin-4 production ^[1]
    • negative regulation of interleukin-5 production ^[1]
    • negative regulation of T cell proliferation ^[1]
    • negative regulation of transcription from RNA polymerase II promoter ^[1]
    • regulation of inflammatory response ^[1]
    • regulation of mRNA stability ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[3]
    • intracellular part ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Scgb1a1
  • participates in the following biological processes:
    • negative regulation of interleukin-13 production ^[1]
    • negative regulation of interleukin-4 production ^[1]
    • negative regulation of interleukin-5 production ^[1]
    • negative regulation of transcription from RNA polymerase II promoter ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Scgb1a1:
  • participates in the following biological processes:
    • response to cytokine stimulus
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum
    • extracellular space
    • nuclear envelope
    • rough endoplasmic reticulum
    • secretory granule

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Scgb1a1 indicates that it:
  • participates in the following biological processes:
    • negative regulation of catalytic activity
  • performs the following molecular functions:
    • phospholipase A2 inhibitor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Hung CH et al. (2004) Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein. J Allergy Clin Immunol, 114:664-70. (PubMed:15356574)
2. Miller LA et al. (2001) Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J Histochem Cytochem, 49:1593-604. (PubMed:11724907)
3. Zhou L et al. (1996) Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem, 44:1183-93. (PubMed:8813084)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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