Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Txn1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Txn1
  • participates in the following biological processes:
    • cell redox homeostasis ^[1]
    • negative regulation of protein export from nucleus ^[1]
    • oxidation-reduction process ^[1]
  • performs the following molecular functions:
    • peptide disulfide oxidoreductase activity ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[2]
    • cytosol ^[1]
    • mitochondrion ^{[3, 4]}
    • nucleus ^{[1, 2]}
• The gene product of Txn1 has been shown to bind to the gene products of Txnip. ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Txn1
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Dnajb5, Txnip ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Txn1:
  • participates in the following biological processes:
    • oxidation-reduction process
    • positive regulation of DNA binding
    • regulation of protein import into nucleus, translocation
    • response to radiation
  • performs the following molecular functions:
    • enzyme binding
    • poly(A) RNA binding
  • is located in the following cellular components:
    • axon
    • cytoplasm
    • cytosol
    • dendrite
    • extracellular vesicular exosome
    • neuronal cell body
    • nucleus

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Summary text based on GO annotations supported by structural data

• Txn1 encodes a protein or proteins that contain the following InterPro domains: Thioredoxin, Thioredoxin domain, Thioredoxin, conserved site, Thioredoxin-like fold, indicating that the gene product:
  • participates in the following biological processes:
    • glycerol ether metabolic process
  • performs the following molecular functions:
    • protein disulfide oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Txn1 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-templated
    • transcription, DNA-templated
    • transport
  • is located in the following cellular components:
    • extracellular region

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References

1. Ago T et al. (2008) A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell, 133:978-93. (PubMed:18555775)
2. Kobayashi M et al. (2000) Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses. Antioxid Redox Signal, 2:653-63. (PubMed:11213470)
3. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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