Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kdm3a. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 6, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kdm3a
  • participates in the following biological processes:
    • histone H3-K9 dimethylation ^[1]
    • positive regulation of transcription from RNA polymerase II promoter ^[1]
  • performs the following molecular functions:
    • core promoter binding ^[2]
    • sequence-specific DNA binding transcription factor activity ^[1]
    • transcription regulatory region sequence-specific DNA binding ^[1]
  • is located in the following cellular components:
    • cytoplasm ^[2]
    • nucleus ^{[2, 3]}
• The gene product of Kdm3a has been shown to bind to the gene products of Mkl1, Mkl2, Myocd. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kdm3a
  • participates in the following biological processes:
    • histone H3-K9 dimethylation ^[1]
    • negative regulation of histone H3-K9 methylation ^[2]
    • spermatid nucleus elongation ^[2]
    • spermatogenesis ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kdm3a:
  • participates in the following biological processes:
    • androgen receptor signaling pathway
    • formaldehyde biosynthetic process
    • histone H3-K9 demethylation
    • hormone-mediated signaling pathway
    • positive regulation of transcription, DNA-dependent
  • performs the following molecular functions:
    • androgen receptor binding
    • iron ion binding
  • is located in the following cellular components:
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kdm3a indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • chromatin modification
    • oxidation-reduction process
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
    • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

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References

1. Lockman K et al. (2007) The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression. Circ Res, 101:e115-23. (PubMed:17991879)
2. Okada Y et al. (2007) Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature, 450:119-23. (PubMed:17943087)
3. Tachibana M et al. (2007) Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J, 26:3346-59. (PubMed:17599069)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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