Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tpo. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tpo
  • is located in the following cellular components:
    • mitochondrion ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tpo:
  • participates in the following biological processes:
    • embryonic hemopoiesis
  • is located in the following cellular components:
    • cell surface
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Tpo encodes a protein or proteins that contain the following InterPro domains: Complement control module, EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Haem peroxidase, Haem peroxidase, animal, Haem peroxidase, animal, subgroup, Sushi/SCR/CCP, indicating that the gene product:
  • participates in the following biological processes:
    • oxidation-reduction process
    • response to oxidative stress
  • performs the following molecular functions:
    • calcium ion binding
    • heme binding
    • peroxidase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tpo indicates that it:
  • participates in the following biological processes:
    • hormone biosynthetic process
    • hydrogen peroxide catabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
    • peroxidase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
• Tpo has been associated with the Enzyme Commission numbers: 1.11.1.8, which implies that the gene product:
  • performs the following molecular functions:
    • iodide peroxidase activity

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References

1. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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