Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tpm2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Tpm2 has been shown to bind to the gene products of Tsen34. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tpm2:
  • participates in the following biological processes:
    • regulation of ATPase activity
  • performs the following molecular functions:
    • actin binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tpm2 indicates that it:
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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References

1. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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