Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tpm1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 30, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tpm1
  • is located in the following cellular components:
    • cytoplasm ^[2]
    • filamentous actin ^[2]
    • myofibril ^{[3, 5]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tpm1
  • participates in the following biological processes:
    • cardiac muscle contraction ^[4]
    • embryo development ^[1]
    • in utero embryonic development ^[5]
    • positive regulation of heart rate by epinephrine ^[4]
    • ventricular cardiac muscle tissue morphogenesis ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tpm1:
  • participates in the following biological processes:
    • actin filament capping
    • cardiac muscle contraction
    • positive regulation of ATPase activity
    • sarcomere organization
    • ventricular cardiac muscle tissue morphogenesis
  • performs the following molecular functions:
    • actin binding
    • actin filament binding
    • cytoskeletal protein binding
    • protein homodimerization activity
    • protein N-terminus binding
  • is located in the following cellular components:
    • actin cytoskeleton
    • bleb
    • cytoplasm
    • protein complex
    • ruffle membrane
    • stress fiber

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tpm1 indicates that it:
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Blanchard EM et al. (1997) Targeted ablation of the murine alpha-tropomyosin gene. Circ Res, 81:1005-10. (PubMed:9400381)
2. McMichael BK et al. (2006) Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts. Bone, 39:694-705. (PubMed:16765662)
3. Patel JR et al. (2001) PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin. Am J Physiol Heart Circ Physiol, 280:H2732-9. (PubMed:11356630)
4. Rajan S et al. (2007) Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res, 101:205-14. (PubMed:17556658)
5. Rethinasamy P et al. (1998) Molecular and physiological effects of alpha-tropomyosin ablation in the mouse [see comments] Circ Res, 82:116-23. (PubMed:9440710)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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