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Gene Ontology Classifications
tropomyosin 1, alpha

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GO curators for mouse genes have assigned the following annotations to the gene product of Tpm1. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 30, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Blanchard EM et al. (1997) Targeted ablation of the murine alpha-tropomyosin gene. Circ Res, 81:1005-10. (PubMed:9400381)
  2. McMichael BK et al. (2006) Tropomyosin isoforms localize to distinct microfilament populations in osteoclasts. Bone, 39:694-705. (PubMed:16765662)
  3. Patel JR et al. (2001) PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin. Am J Physiol Heart Circ Physiol, 280:H2732-9. (PubMed:11356630)
  4. Rajan S et al. (2007) Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res, 101:205-14. (PubMed:17556658)
  5. Rethinasamy P et al. (1998) Molecular and physiological effects of alpha-tropomyosin ablation in the mouse [see comments] Circ Res, 82:116-23. (PubMed:9440710)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory