Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tpi1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 15, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tpi1
  • participates in the following biological processes:
    • glucose metabolic process ^[4]
    • glyceraldehyde-3-phosphate metabolic process ^[6]
  • performs the following molecular functions:
    • isomerase activity ^[3]
    • triose-phosphate isomerase activity ^{[2, 4, 5, 6]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tpi1
  • participates in the following biological processes:
    • embryo development ^[4]
    • metabolic process ^[1]
    • multicellular organismal development ^[1]
  • performs the following molecular functions:
    • triose-phosphate isomerase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tpi1:
  • participates in the following biological processes:
    • carbohydrate metabolic process
  • performs the following molecular functions:
    • triose-phosphate isomerase activity
  • is located in the following cellular components:
    • cytosol
    • nucleus

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Summary text based on GO annotations supported by structural data

• Tpi1 encodes a protein or proteins that contain the following InterPro domains: Aldolase-type TIM barrel, Triosephosphate isomerase, Triosephosphate isomerase, active site, Triosephosphate isomerase, bacterial/eukaryotic, indicating that the gene product:
  • participates in the following biological processes:
    • glycolysis
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tpi1 indicates that it:
  • participates in the following biological processes:
    • gluconeogenesis
    • glycolysis
    • pentose-phosphate shunt

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References

1. Charles DJ et al. (1987) Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res, 176:81-91. (PubMed:3796661)
2. Kozak CA et al. (1977) Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet, 3:121-33. (PubMed:204065)
3. Leinwand LA et al. (1978) Assignment of the genes for triose phosphate isomerase to chromosome 6 and tripeptidase-1 to chromosome 10 in Mus musculus by somatic cell hybridization. Somatic Cell Genet, 4:233-40. (PubMed:566475)
4. Merkle S et al. (1989) Characterization of triosephosphate isomerase mutants with reduced enzyme activity in Mus musculus. Genetics, 123:837-44. (PubMed:2693209)
5. Minna JD et al. (1978) Assignment of a Mus musculus gene for triosephosphate isomerase to chromosome 6 and for glyoxalase-I to chromosome 17 using somatic cell hybrids. Somatic Cell Genet, 4:241-52. (PubMed:566476)
6. White RA et al. (2004) Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse. Blood, 104:1511-8. (PubMed:15155459)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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