Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA topoisomerase II alpha).