Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tnnc1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 19, 2007. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tnnc1
  • participates in the following biological processes:
    • regulation of ATPase activity ^[2]
  • performs the following molecular functions:
    • actin filament binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tnnc1
  • participates in the following biological processes:
    • regulation of muscle filament sliding speed ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tnnc1:
  • participates in the following biological processes:
    • cardiac muscle contraction
    • diaphragm contraction
    • regulation of muscle contraction
    • response to metal ion
    • ventricular cardiac muscle tissue morphogenesis
  • performs the following molecular functions:
    • calcium ion binding
    • calcium-dependent protein binding
    • protein homodimerization activity
    • troponin I binding
    • troponin T binding
  • is located in the following cellular components:
    • contractile fiber
    • troponin complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tnnc1 indicates that it:
  • performs the following molecular functions:
    • metal ion binding

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References

1. Homsher E et al. (2000) Regulation of force and unloaded sliding speed in single thin filaments: effects of regulatory proteins and calcium. J Physiol, 524 Pt 1:233-43. (PubMed:10747195)
2. Huynh Q et al. (1996) Effects of cardiac thin filament Ca2+: statistical mechanical analysis of a troponin C site II mutant. Biophys J, 70:1447-55. (PubMed:8785301)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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