Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables chromatin DNA binding activity; nuclear receptor activity; and transcription cis-regulatory region binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; positive regulation of cold-induced thermogenesis; and positive regulation of thyroid hormone mediated signaling pathway. Acts upstream of or within several processes, including cartilage condensation; female mating behavior; and type I pneumocyte differentiation. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Orthologous to human THRA (thyroid hormone receptor alpha).