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Gene Ontology Classifications
thyroid hormone receptor alpha

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GO curators for mouse genes have assigned the following annotations to the gene product of Thra. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Casas F et al. (2006) Characterization of a Novel Thyroid Hormone Receptor {alpha} Variant Involved in the Regulation of Myoblast Differentiation. Mol Endocrinol, 20:749-63. (PubMed:16322094)
  2. Compe E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci, 10:1414-22. (PubMed:17952069)
  3. Dellovade TL et al. (2000) The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors. Nat Neurosci, 3:472-5. (PubMed:10769387)
  4. Eckey M et al. (2003) Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Mol Cell Endocrinol, 213:71-8. (PubMed:15062575)
  5. Flamant F et al. (2002) Congenital Hypothyroid Pax8(-/-) Mutant Mice Can Be Rescued by Inactivating the TRalpha Gene. Mol Endocrinol, 16:24-32. (PubMed:11773436)
  6. Fraichard A et al. (1997) The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production. EMBO J, 16:4412-20. (PubMed:9250685)
  7. Gauthier K et al. (1999) Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. EMBO J, 18:623-31. (PubMed:9927422)
  8. Kendrick TS et al. (2008) Erythroid defects in TR{alpha}-/- mice. Blood, 111:3245-8. (PubMed:18203951)
  9. Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem, 279:48329-41. (PubMed:15322135)
  10. Liu YY et al. (2003) A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem, 278:38913-20. (PubMed:12869545)
  11. Mai W et al. (2004) Thyroid hormone receptor alpha is a molecular switch of cardiac function between fetal and postnatal life. Proc Natl Acad Sci U S A, 101:10332-7. (PubMed:15240882)
  12. Malik S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol, 24:8244-54. (PubMed:15340084)
  13. Pei L et al. (2011) Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med, 17:1466-72. (PubMed:22001906)
  14. Potter GB et al. (2001) The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. Genes Dev, 15:2687-701. (PubMed:11641275)
  15. Schmutz I et al. (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev, 24:345-57. (PubMed:20159955)
  16. Wikstrom L et al. (1998) Abnormal heart rate and body temperature in mice lacking thyroid hormone receptor alpha 1. EMBO J, 17:455-61. (PubMed:9430637)
  17. Wilcoxon JS et al. (2007) Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha. Behav Brain Res, 177:109-16. (PubMed:17129617)
  18. Xu B et al. (2004) An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation. J Biol Chem, 279:33051-6. (PubMed:15180993)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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