Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Thbd. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Thbd
  • participates in the following biological processes:
    • embryo development ^[1]
    • female pregnancy ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Thbd:
  • participates in the following biological processes:
    • blood coagulation
  • is located in the following cellular components:
    • cell surface
    • extracellular space
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Thbd encodes a protein or proteins that contain the following InterPro domains: C-type lectin, C-type lectin fold, C-type lectin-like, Complement component C1q/Thrombomodulin, EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Growth factor, receptor, Thrombomodulin, Thrombomodulin-like, EGF-like, indicating that the gene product:
  • performs the following molecular functions:
    • calcium ion binding
    • carbohydrate binding
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Thbd indicates that it:
  • participates in the following biological processes:
    • hemostasis
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Healy AM et al. (1995) Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci U S A, 92:850-4. (PubMed:7846065)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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