Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tgm1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tgm1
  • is located in the following cellular components:
    • cell-cell adherens junction ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tgm1
  • participates in the following biological processes:
    • organ morphogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tgm1:
  • participates in the following biological processes:
    • keratinocyte differentiation
  • performs the following molecular functions:
    • protein-glutamine gamma-glutamyltransferase activity
  • is located in the following cellular components:
    • intrinsic to membrane

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Summary text based on GO annotations supported by structural data

• Tgm1 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Immunoglobulin-like fold, Protein-glutamine gamma-glutamyltransferase, eukaryota, Transglutaminase, C-terminal, Transglutaminase, conserved site, Transglutaminase, N-terminal, Transglutaminase-like, indicating that the gene product:
  • participates in the following biological processes:
    • peptide cross-linking

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tgm1 indicates that it:
  • participates in the following biological processes:
    • keratinization
  • performs the following molecular functions:
    • metal ion binding
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • membrane

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References

1. Hiiragi T et al. (1999) Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells. J Biol Chem, 274:34148-54. (PubMed:10567386)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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