Automated description from the Alliance of Genome Resources
Exhibits several functions, including SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Predicted to contribute to growth factor binding activity. Involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of cellular component organization. Localizes to the endosome. Used to study Loeys-Dietz syndrome; osteoarthritis; and systemic scleroderma. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).