About   Help   FAQ
Gene Ontology Classifications
transforming growth factor, beta receptor I

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tgfbr1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Andersson O et al. (2006) Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep, 7:831-7. (PubMed:16845371)
  2. Blaney Davidson EN et al. (2009) Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice. J Immunol, 182:7937-45. (PubMed:19494318)
  3. Chen CL et al. (2007) Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci, 120:3509-21. (PubMed:17878231)
  4. Chuva de Sousa Lopes SM et al. (2005) Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5. Dev Biol, 284:194-203. (PubMed:15993878)
  5. de Iongh RU et al. (2001) Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development, 128:3995-4010. (PubMed:11641223)
  6. Dudas M et al. (2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol, 266:96-108. (PubMed:14729481)
  7. Dudas M et al. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol, 296:298-314. (PubMed:16806156)
  8. Goumans MJ et al. (2003) Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling. Mol Cell, 12:817-28. (PubMed:14580334)
  9. Hao X et al. (2011) SNX25 regulates TGF-beta signaling by enhancing the receptor degradation. Cell Signal, 23:935-46. (PubMed:21266196)
  10. Larsson J et al. (2001) Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J, 20:1663-73. (PubMed:11285230)
  11. Lee MK et al. (2007) TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J, 26:3957-67. (PubMed:17673906)
  12. Liu W et al. (2006) Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia. EMBO J, 25:1646-58. (PubMed:16601693)
  13. Miles DC et al. (2013) Signaling through the TGF beta-activin receptors ALK4/5/7 regulates testis formation and male germ cell development. PLoS One, 8:e54606. (PubMed:23342175)
  14. Okano J et al. (2005) Transforming growth factor beta2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. Int J Dev Biol, 49:23-31. (PubMed:15744664)
  15. Roelen BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation, 64:19-31. (PubMed:9921650)
  16. Rudini N et al. (2008) VE-cadherin is a critical endothelial regulator of TGF-beta signalling. EMBO J, 27:993-1004. (PubMed:18337748)
  17. Seki T et al. (2006) Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab Invest, 86:116-29. (PubMed:16344855)
  18. Sezaki T et al. (2013) Dlg5 interacts with the TGF-beta receptor and promotes its degradation. FEBS Lett, 587:1624-9. (PubMed:23624079)
  19. Stenvers KL et al. (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol, 23:4371-85. (PubMed:12773577)
  20. Wang J et al. (2006) Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol, 6:51. (PubMed:17078885)
  21. Wang X et al. (2013) LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling. Nature, 499:306-11. (PubMed:23868260)
  22. Xie L et al. (2011) Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-beta in endothelial cells. Am J Physiol Cell Physiol, 301:C1161-74. (PubMed:21832243)
  23. Yamashita M et al. (2005) Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell, 121:101-13. (PubMed:15820682)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory