Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable several functions, including cytokine activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including face morphogenesis; positive regulation of SMAD protein signal transduction; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including positive regulation of filopodium assembly; positive regulation of transcription by RNA polymerase II; and regulation of apoptotic process. Located in extracellular matrix. Is expressed in several structures, including alimentary system; embryo mesenchyme; heart and pericardium; sensory organ; and skin. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3).