Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tgfb3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tgfb3
  • participates in the following biological processes:
    • cellular response to growth factor stimulus ^[1]
    • mammary gland development ^[9]
    • negative regulation of cell proliferation ^[2]
  • is located in the following cellular components:
    • extracellular matrix ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Tgfb3
  • participates in the following biological processes:
    • embryo development ^[3]
    • in utero embryonic development ^[3]
    • induction of apoptosis ^[4]
    • lung alveolus development ^[6]
    • negative regulation of neuron apoptotic process ^[10]
    • organ morphogenesis ^[7]
    • palate development ^{[6, 8]}
    • positive regulation of epithelial to mesenchymal transition ^[8]
    • positive regulation of filopodium assembly ^[4]
    • positive regulation of pathway-restricted SMAD protein phosphorylation ^[8]
    • positive regulation of SMAD protein import into nucleus ^[8]
    • positive regulation of transcription, DNA-dependent ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of Tgfb3
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter based on interactions with Hipk2, Smad2, Smad3, Smad4 ^[10]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tgfb3:
  • participates in the following biological processes:
    • activation of MAPK activity
    • cell-cell junction organization
    • detection of hypoxia
    • embryonic neurocranium morphogenesis
    • face morphogenesis
    • negative regulation of cell proliferation
    • negative regulation of DNA replication
    • negative regulation of macrophage cytokine production
    • negative regulation of transforming growth factor beta receptor signaling pathway
    • positive regulation of apoptotic process
    • positive regulation of collagen biosynthetic process
    • positive regulation of DNA replication
    • positive regulation of epithelial to mesenchymal transition
    • positive regulation of protein secretion
    • positive regulation of transcription, DNA-dependent
    • response to estrogen stimulus
    • response to hypoxia
    • response to progesterone stimulus
    • SMAD protein import into nucleus
    • transforming growth factor beta receptor signaling pathway
  • performs the following molecular functions:
    • identical protein binding
    • protein heterodimerization activity
    • transforming growth factor beta binding
    • type I transforming growth factor beta receptor binding
    • type II transforming growth factor beta receptor binding
  • is located in the following cellular components:
    • cell surface
    • cytoplasm
    • extracellular matrix
    • extracellular space
    • neuronal cell body
    • nucleus
    • secretory granule
    • T-tubule

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Summary text based on GO annotations supported by structural data

• Tgfb3 encodes a protein or proteins that contain the following InterPro domains: Transforming growth factor beta 3, Transforming growth factor beta, conserved site, Transforming growth factor-beta, Transforming growth factor-beta, C-terminal, Transforming growth factor-beta, N-terminal, Transforming growth factor-beta-related, indicating that the gene product:
  • participates in the following biological processes:
    • cell growth
    • growth
  • performs the following molecular functions:
    • growth factor activity
    • transforming growth factor beta receptor binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tgfb3 indicates that it:
  • participates in the following biological processes:
    • positive regulation of cell division
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Begue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol, 38:405-20. (PubMed:7848824)
2. Cui XM et al. (2003) TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn, 227:387-94. (PubMed:12815624)
3. Dudas M et al. (2004) Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol, 266:96-108. (PubMed:14729481)
4. Dudas M et al. (2006) Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol, 296:298-314. (PubMed:16806156)
5. Jaskoll T et al. (1999) Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec, 256:252-68. (PubMed:10521784)
6. Kaartinen V et al. (1995) Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat Genet, 11:415-21. (PubMed:7493022)
7. Martinez-Alvarez C et al. (2004) Snail family members and cell survival in physiological and pathological cleft palates. Dev Biol, 265:207-18. (PubMed:14697364)
8. Nawshad A et al. (2003) TGF{beta}3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J Cell Biol, 163:1291-1301. (PubMed:14691138)
9. Robinson SD et al. (1991) Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development. Development, 113:867-78. (PubMed:1821856)
10. Zhang J et al. (2007) Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci, 10:77-86. (PubMed:17159989)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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