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Gene Ontology Classifications
transforming growth factor, beta 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Tgfb2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Andrews ZB et al. (2006) Transforming growth factor beta2 haploinsufficient mice develop age-related nigrostriatal dopamine deficits. Neurobiol Dis, 21:568-75. (PubMed:16257223)
  2. Anthwal N et al. (2008) The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn, 237:1604-13. (PubMed:18498113)
  3. Azhar M et al. (2011) Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn, null:null. (PubMed:21780244)
  4. Baffi MO et al. (2004) Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones. Dev Biol, 276:124-42. (PubMed:15531369)
  5. Cheng HL et al. (1993) TGF-beta 2 gene and protein expression in maternal and fetal tissues at various stages of murine development. J Reprod Immunol, 25:133-48. (PubMed:8164195)
  6. Combs MD et al. (2013) Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. J Biol Chem, 288:28869-80. (PubMed:23963447)
  7. Foitzik K et al. (1999) The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis. Dev Biol, 212:278-89. (PubMed:10433821)
  8. Grass S et al. (1996) Alterations in somite patterning of Myf-5-deficient mice: a possible role for FGF-4 and FGF-6. Development, 122:141-50. (PubMed:8565825)
  9. Hao X et al. (2011) SNX25 regulates TGF-beta signaling by enhancing the receptor degradation. Cell Signal, 23:935-46. (PubMed:21266196)
  10. Jamora C et al. (2005) A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol, 3:e11. (PubMed:15630473)
  11. Langer JC et al. (2004) Quantitative Trait Analysis Reveals Transforming Growth Factor-{beta}2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function. J Exp Med, 199:5-14. (PubMed:14707111)
  12. Molin DG et al. (2002) Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfbeta2 knock-out mice. Cardiovasc Res, 56:312-22. (PubMed:12393102)
  13. Molin DG et al. (2004) Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development. Circ Res, 95:1109-17. (PubMed:15528466)
  14. Okano J et al. (2005) Transforming growth factor beta2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. Int J Dev Biol, 49:23-31. (PubMed:15744664)
  15. Paliwal S et al. (2004) P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem Biophys Res Commun, 315:1104-9. (PubMed:14985127)
  16. Saika S et al. (2001) TGFbeta2 in corneal morphogenesis during mouse embryonic development. Dev Biol, 240:419-32. (PubMed:11784073)
  17. Stenvers KL et al. (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol, 23:4371-85. (PubMed:12773577)
  18. Tocharus J et al. (2004) Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ, 46:257-74. (PubMed:15206957)
  19. Weller M et al. (1994) Transforming growth factor-beta 2 induces apoptosis of murine T cell clones without down-regulating bcl-2 mRNA expression. Eur J Immunol, 24:1293-300. (PubMed:8206089)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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