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Gene Ontology Classifications
transforming growth factor, beta 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tgfb1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Begue-Kirn C et al. (1994) Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation. Int J Dev Biol, 38:405-20. (PubMed:7848824)
  2. Bommireddy R et al. (2003) TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes. J Immunol, 170:3645-52. (PubMed:12646629)
  3. Chang NS. (2002) The Non-ankyrin C Terminus of Ikappa Balpha Physically Interacts with p53 in Vivo and Dissociates in Response to Apoptotic Stress, Hypoxia, DNA Damage, and Transforming Growth Factor-beta 1-mediated Growth Suppression. J Biol Chem, 277:10323-31. (PubMed:11799106)
  4. Chen CL et al. (2007) Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis. J Cell Sci, 120:3509-21. (PubMed:17878231)
  5. Chuva de Sousa Lopes SM et al. (2005) Altered primordial germ cell migration in the absence of transforming growth factor beta signaling via ALK5. Dev Biol, 284:194-203. (PubMed:15993878)
  6. Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol, 9:1347-55. (PubMed:18997793)
  7. Falix FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol, 396:201-13. (PubMed:25446530)
  8. Fantini MC et al. (2004) Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol, 172:5149-53. (PubMed:15100250)
  9. Fuentes-Calvo I et al. (2013) The small GTPase N-Ras regulates extracellular matrix synthesis, proliferation and migration in fibroblasts. Biochim Biophys Acta, 1833:2734-44. (PubMed:23871832)
  10. Ghosh M et al. (2007) Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem, 282:11676-86. (PubMed:17293613)
  11. Heine UI et al. (1990) Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis. Development, 109:29-36. (PubMed:2209468)
  12. Hirano M et al. (2008) EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. J Cell Biol, 182:1217-30. (PubMed:18794329)
  13. Ingman WV et al. (2008) Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod, 79:711-7. (PubMed:18614704)
  14. Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J, 26:3132-43. (PubMed:17568773)
  15. Kang JS et al. (2005) Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J, 24:2543-55. (PubMed:15990875)
  16. Kaplan DH et al. (2007) Autocrine/paracrine TGF{beta}1 is required for the development of epidermal Langerhans cells. J Exp Med, 204:2545-52. (PubMed:17938236)
  17. Karamboulas K et al. (2010) Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals. J Cell Sci, 123:2068-76. (PubMed:20501701)
  18. Kettunen P et al. (2007) Fgfr2b mediated epithelial-mesenchymal interactions coordinate tooth morphogenesis and dental trigeminal axon patterning. Mech Dev, 124:868-83. (PubMed:17951031)
  19. Kettunen P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgf{beta}1 regulate semaphorin 3a expression in the dental mesenchyme. Development, 132:323-334. (PubMed:15604101)
  20. Kulkarni AB et al. (1993) Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A, 90:770-4. (PubMed:8421714)
  21. Li MO et al. (2007) T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation. Immunity, 26:579-91. (PubMed:17481928)
  22. Liu D et al. (2001) TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev, 15:2950-66. (PubMed:11711431)
  23. Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev, 22:3121-34. (PubMed:19056892)
  24. Morishima N et al. (2009) TGF-beta is necessary for induction of IL-23R and Th17 differentiation by IL-6 and IL-23. Biochem Biophys Res Commun, 386:105-10. (PubMed:19501566)
  25. Nakajima Y et al. (1997) Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart. J Cell Biol, 136:193-204. (PubMed:9008713)
  26. Oganesian A et al. (2006) The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function. J Biol Chem, 281:38507-18. (PubMed:17018525)
  27. Paliwal S et al. (2004) P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochem Biophys Res Commun, 315:1104-9. (PubMed:14985127)
  28. Roarty K et al. (2007) Wnt5a is required for proper mammary gland development and TGF-{beta}-mediated inhibition of ductal growth. Development, 134:3929-39. (PubMed:17898001)
  29. Robinson SD et al. (1991) Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development. Development, 113:867-78. (PubMed:1821856)
  30. Roelen BA et al. (1998) Identification of two distinct functions for TGF-beta in early mouse development. Differentiation, 64:19-31. (PubMed:9921650)
  31. Salazar KD et al. (2009) Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts. Am J Physiol Lung Cell Mol Physiol, 297:L1002-11. (PubMed:19734317)
  32. Shull MM et al. (1992) Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature, 359:693-9. (PubMed:1436033)
  33. Stegeman S et al. (2013) Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis. PLoS One, 8:e68287. (PubMed:23861879)
  34. Stenvers KL et al. (2003) Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol, 23:4371-85. (PubMed:12773577)
  35. Sterner-Kock A et al. (2002) Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev, 16:2264-73. (PubMed:12208849)
  36. Subramanian SV et al. (2004) Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators. Mol Biol Cell, 15:4532-43. (PubMed:15282343)
  37. Tocharus J et al. (2004) Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Dev Growth Differ, 46:257-74. (PubMed:15206957)
  38. Wakida N et al. (2006) Inhibition of prostasin-induced ENaC activities by PN-1 and regulation of PN-1 expression by TGF-beta1 and aldosterone. Kidney Int, 70:1432-8. (PubMed:16941024)
  39. Wang X et al. (2013) LRG1 promotes angiogenesis by modulating endothelial TGF-beta signalling. Nature, 499:306-11. (PubMed:23868260)
  40. Wilkinson DS et al. (2008) Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol, 28:1988-98. (PubMed:18212064)
  41. Wilkinson DS et al. (2005) A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol, 25:1200-12. (PubMed:15657445)
  42. Wu G et al. (2007) The anaphase-promoting complex coordinates initiation of lens differentiation. Mol Biol Cell, 18:1018-29. (PubMed:17215516)
  43. Wu JA et al. (2008) Murine pregnancy-specific glycoprotein 23 induces the proangiogenic factors transforming-growth factor beta 1 and vascular endothelial growth factor a in cell types involved in vascular remodeling in pregnancy. Biol Reprod, 79:1054-61. (PubMed:18753609)
  44. Yaddanapudi S et al. (2011) CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival. J Clin Invest, 121:3965-80. (PubMed:21911934)
  45. Yamashita M et al. (2005) Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell, 121:101-13. (PubMed:15820682)
  46. Yun EJ et al. (2012) mSmile is Necessary for Bronchial Smooth Muscle and Alveolar Myofibroblast Development. Anat Rec (Hoboken), 295:167-76. (PubMed:21956870)
  47. Zhou L et al. (2008) TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature, 453:236-40. (PubMed:18368049)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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