Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tec. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Tec has been shown to bind to the gene products of Stap1. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Tec:
  • participates in the following biological processes:
    • B cell receptor signaling pathway
    • integrin-mediated signaling pathway
    • protein phosphorylation
    • regulation of platelet activation
  • performs the following molecular functions:
    • non-membrane spanning protein tyrosine kinase activity
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton

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Summary text based on GO annotations supported by structural data

• Tec encodes a protein or proteins that contain the following InterPro domains: Pleckstrin homology domain, Pleckstrin homology-like domain, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Serine-threonine/tyrosine-protein kinase catalytic domain, SH2 domain, Src homology-3 domain, Tyrosine-protein kinase, active site, Tyrosine-protein kinase, catalytic domain, Zinc finger, Btk motif, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction
  • performs the following molecular functions:
    • ATP binding
    • phospholipid binding
    • protein kinase activity
    • protein tyrosine kinase activity
    • transferase activity, transferring phosphorus-containing groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tec indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • lipid binding
    • metal ion binding
    • nucleotide binding
    • protein tyrosine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • membrane
    • plasma membrane

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References

1. Yokohari K et al. (2001) Isoform-Dependent Interaction of BRDG1 with Tec Kinase. Biochem Biophys Res Commun, 289:414-20. (PubMed:11716489)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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