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Gene Ontology Classifications
sex determining region of Chr Y

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sry. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text for additional MGI annotations
  1. Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet, 18:2989-3001. (PubMed:19457926)
  2. Collignon J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2 Development, 122:509-20. (PubMed:8625802)
  3. Giese K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev, 9:995-1008. (PubMed:7774816)
  4. Gomez G et al. (2005) TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J Immunol, 174:5987-93. (PubMed:15879091)
  5. Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol, 4:e187. (PubMed:16700629)
  6. Ng CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res, 40:4933-41. (PubMed:22344693)
  7. Nishino K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev Growth Differ, 44:35-43. (PubMed:11869290)
  8. Oh HJ et al. (2005) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod, 72:407-15. (PubMed:15469996)
  9. Peng H et al. (2009) Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J Biol Chem, 284:35670-80. (PubMed:19850934)
  10. Swain A et al. (1998) Dax1 antagonizes Sry action in mammalian sex determination. Nature, 391:761-7. (PubMed:9486644)
  11. Wilhelm D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol, 287:111-24. (PubMed:16185683)
  12. Zerlanko BJ et al. (2012) Premature senescence and increased TGFbeta signaling in the absence of Tgif1. PLoS One, 7:e35460. (PubMed:22514746)
  13. Zhang J et al. (1999) In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol, 43:219-27. (PubMed:10410901)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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