Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sry. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Sry
  • participates in the following biological processes:
    • male gonad development ^[1]
    • negative regulation of gene expression ^[7]
    • regulation of transcription from RNA polymerase II promoter ^[6]
    • transcription from RNA polymerase II promoter ^[6]
  • performs the following molecular functions:
    • DNA binding ^[2]
    • DNA binding, bending ^[3]
    • protein heterodimerization activity ^[6]
    • sequence-specific DNA binding RNA polymerase II transcription factor activity ^[6]
  • is located in the following cellular components:
    • nuclear transcription factor complex ^[6]
    • nucleus ^{[8, 11, 12]}
• The gene product of Sry has been shown to bind to the gene products of Slc9a3r2. ^{[8, 9, 13]}
• Researchers have inferred, based on genetic interactions, that the gene product of Sry
  • participates in the following biological processes:
    • male sex determination based on interactions with Fgf9, Nr0b1, Sox9 ^{[4, 5]}
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Sry ^[9]
    • sex determination based on interactions with Nr0b1 ^[10]

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sry indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • regulation of transcription, DNA-templated
    • sex differentiation
    • transcription, DNA-templated
  • performs the following molecular functions:
    • calmodulin binding
  • is located in the following cellular components:
    • cytoplasm

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References

1. Buaas FW et al. (2009) The transcription co-factor CITED2 functions during sex determination and early gonad development. Hum Mol Genet, 18:2989-3001. (PubMed:19457926)
2. Collignon J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2 Development, 122:509-20. (PubMed:8625802)
3. Giese K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev, 9:995-1008. (PubMed:7774816)
4. Gomez G et al. (2005) TGF-beta 1 inhibits mast cell Fc epsilon RI expression. J Immunol, 174:5987-93. (PubMed:15879091)
5. Kim Y et al. (2006) Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol, 4:e187. (PubMed:16700629)
6. Ng CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res, 40:4933-41. (PubMed:22344693)
7. Nishino K et al. (2002) Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by Sry. Dev Growth Differ, 44:35-43. (PubMed:11869290)
8. Oh HJ et al. (2005) Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol Reprod, 72:407-15. (PubMed:15469996)
9. Peng H et al. (2009) Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery. J Biol Chem, 284:35670-80. (PubMed:19850934)
10. Swain A et al. (1998) Dax1 antagonizes Sry action in mammalian sex determination. Nature, 391:761-7. (PubMed:9486644)
11. Wilhelm D et al. (2005) Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol, 287:111-24. (PubMed:16185683)
12. Zerlanko BJ et al. (2012) Premature senescence and increased TGFbeta signaling in the absence of Tgif1. PLoS One, 7:e35460. (PubMed:22514746)
13. Zhang J et al. (1999) In vitro binding and expression studies demonstrate a role for the mouse Sry Q-rich domain in sex determination. Int J Dev Biol, 43:219-27. (PubMed:10410901)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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