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Gene Ontology Classifications
HNF1 homeobox A

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hnf1a. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of January 2, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Akiyama TE et al. (2000) Regulation of the liver fatty acid-binding protein gene by hepatocyte nuclear factor 1alpha (HNF1alpha). Alterations in fatty acid homeostasis in HNF1alpha-deficient mice. J Biol Chem, 275:27117-22. (PubMed:10852923)
  2. Blumenfeld M et al. (1991) Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse. Development, 113:589-99. (PubMed:1685988)
  3. Bosse T et al. (2006) Hepatocyte nuclear factor-1alpha is required for expression but dispensable for histone acetylation of the lactase-phlorizin hydrolase gene in vivo. Am J Physiol Gastrointest Liver Physiol, 290:G1016-24. (PubMed:16223943)
  4. Bosse T et al. (2007) Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol, 292:G1302-14. (PubMed:17272516)
  5. Cereghini S et al. (1992) Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental roles. Development, 116:783-97. (PubMed:1363228)
  6. Cheret C et al. (2002) Hepatocyte Nuclear Factor 1 alpha Controls Renal Expression of the Npt1-Npt4 Anionic Transporter Locus. J Mol Biol, 322:929. (PubMed:12367519)
  7. De Simone V et al. (1991) LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia. EMBO J, 10:1435-43. (PubMed:1673925)
  8. Dukes ID et al. (1998) Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice. J Biol Chem, 273:24457-64. (PubMed:9733737)
  9. Faure AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res, 22:2163-75. (PubMed:22780989)
  10. Galceran J et al. (2000) Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development, 127:469-82. (PubMed:10631168)
  11. Galceran J et al. (1999) Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev, 13:709-17. (PubMed:10090727)
  12. Glass DA 2nd et al. (2005) Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell, 8:751-64. (PubMed:15866165)
  13. Grimm AA et al. (2011) A nutrient-sensitive interaction between Sirt1 and HNF-1alpha regulates Crp expression. Aging Cell, 10:305-17. (PubMed:21176092)
  14. Hiesberger T et al. (2005) Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. J Biol Chem, 280:10578-86. (PubMed:15647252)
  15. Hiesberger T et al. (2004) Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice. J Clin Invest, 113:814-25. (PubMed:15067314)
  16. Hiraiwa H et al. (2001) A molecular link between the common phenotypes of type 1 glycogen storage disease and HNF1alpha-null mice. J Biol Chem, 276:7963-7. (PubMed:11121425)
  17. Jakowlew SB et al. (1998) Reduction in transforming growth factor-beta type II receptor in mouse lung carcinogenesis. Mol Carcinog, 22:46-56. (PubMed:9609100)
  18. Kamiya A et al. (2004) Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett, 578:63-8. (PubMed:15581617)
  19. Kuo CJ et al. (1990) Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1. Proc Natl Acad Sci U S A, 87:9838-42. (PubMed:2263635)
  20. Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev, 20:2293-305. (PubMed:16912278)
  21. Lee YH et al. (1998) Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1alpha knockout mouse. Mol Cell Biol, 18:3059-68. (PubMed:9566924)
  22. Luco RF et al. (2006) A conditional model reveals that induction of hepatocyte nuclear factor-1alpha in Hnf1alpha-null mutant beta-cells can activate silenced genes postnatally, whereas overexpression is deleterious. Diabetes, 55:2202-11. (PubMed:16873682)
  23. Maestro MA et al. (2003) Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas. Hum Mol Genet, 12:3307-14. (PubMed:14570708)
  24. Mendel DB et al. (1991) HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro. Genes Dev, 5:1042-56. (PubMed:2044952)
  25. Miura N et al. (1993) Immunological characterization of hepatocyte nuclear factor 1 protein: appearance of hepatocyte nuclear factor 1 protein in developing mouse embryos. Eur J Cell Biol, 60:376-82. (PubMed:8330635)
  26. Miura N et al. (1993) MFH-1, a new member of the fork head domain family, is expressed in developing mesenchyme. FEBS Lett, 326:171-6. (PubMed:8325367)
  27. Mouchel N et al. (2004) HNF1alpha is involved in tissue-specific regulation of CFTR gene expression. Biochem J, 378:909-18. (PubMed:14656222)
  28. Muppala V et al. (2000) The role of HNF-1alpha in controlling hepatic catalase activity. Mol Pharmacol, 57:93-100. (PubMed:10617683)
  29. Nammo T et al. (2002) Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas. Diabetologia, 45:1142-53. (PubMed:12189445)
  30. Pare JF et al. (2004) The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J Biol Chem, 279:21206-16. (PubMed:15014077)
  31. Pontoglio M et al. (2000) HNF1alpha controls renal glucose reabsorption in mouse and man. EMBO Rep, 1:359-65. (PubMed:11269503)
  32. Pontoglio M et al. (1996) Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell, 84:575-85. (PubMed:8598044)
  33. Pontoglio M et al. (2001) Hepatocyte nuclear factor 1alpha controls the expression of terminal complement genes. J Exp Med, 194:1683-9. (PubMed:11733582)
  34. Pontoglio M et al. (1998) Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest, 101:2215-22. (PubMed:9593777)
  35. Rose RB et al. (2000) High-resolution structure of the HNF-1alpha dimerization domain. Biochemistry, 39:15062-70. (PubMed:11106484)
  36. Rose RB et al. (2004) Biochemical and structural basis for partially redundant enzymatic and transcriptional functions of DCoH and DCoH2. Biochemistry, 43:7345-55. (PubMed:15182178)
  37. Sato Y et al. (2012) Anks4b, a novel target of HNF4alpha protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic beta-cells. J Biol Chem, 287:23236-45. (PubMed:22589549)
  38. Shih DQ et al. (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet, 27:375-82. (PubMed:11279518)
  39. Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev, 12:107-19. (PubMed:9420335)
  40. Streeper RS et al. (1998) Hepatocyte nuclear factor-1 acts as an accessory factor to enhance the inhibitory action of insulin on mouse glucose-6-phosphatase gene transcription. Proc Natl Acad Sci U S A, 95:9208-13. (PubMed:9689059)
  41. Tomomura M et al. (1994) Abnormal gene expression and regulation in the liver of jvs mice with systemic carnitine deficiency. Biochim Biophys Acta, 1226:307-14. (PubMed:7914432)
  42. Torres-Padilla ME et al. (2006) Role of TIF1{alpha} as a modulator of embryonic transcription in the mouse zygote. J Cell Biol, 174:329-38. (PubMed:16880268)
  43. Wang L et al. (2004) Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release. Endocrinology, 145:3941-9. (PubMed:15142986)
  44. Wolfrum C et al. (2005) Apolipoprotein M is required for prebeta-HDL formation and cholesterol efflux to HDL and protects against atherosclerosis. Nat Med, 11:418-22. (PubMed:15793583)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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