Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein dimerization activity. Involved in several processes, including glucose homeostasis; glucose transmembrane transport; and positive regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic morphogenesis; lipid transport; and monocarboxylic acid biosynthetic process. Located in cytoplasm; photoreceptor outer segment; and pronucleus. Part of transcription regulator complex. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; septum transversum hepatic component; and spleen. Used to study maturity-onset diabetes of the young type 3; phenylketonuria; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; glucose metabolism disease (multiple); liver disease (multiple); and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A).