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Gene Ontology Classifications
T-box 3

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GO curators for mouse genes have assigned the following annotations to the gene product of Tbx3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This protein is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar-mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bakker ML et al. (2008) Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res, 102:1340-9. (PubMed:18467625)
  2. Boogerd KJ et al. (2008) Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43. Cardiovasc Res, 78:485-93. (PubMed:18285513)
  3. Brummelkamp TR et al. (2002) TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence. J Biol Chem, 277:6567-72. (PubMed:11748239)
  4. Cho KW et al. (2006) Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development. Proc Natl Acad Sci U S A, 103:16788-93. (PubMed:17071745)
  5. Davenport TG et al. (2003) Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development, 130:2263-73. (PubMed:12668638)
  6. Eriksson KS et al. (2009) T-box 3 is expressed in the adult mouse hypothalamus and medulla. Brain Res, 1302:233-9. (PubMed:19765559)
  7. Frank DU et al. (2013) Mouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndrome. PLoS One, 8:e67841. (PubMed:23844108)
  8. Hoogaars WM et al. (2007) Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Genes Dev, 21:1098-112. (PubMed:17473172)
  9. Jerome-Majewska LA et al. (2005) Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev Dyn, 234:922-33. (PubMed:16222716)
  10. Mesbah K et al. (2008) Tbx3 is required for outflow tract development. Circ Res, 103:743-50. (PubMed:18723448)
  11. Mommersteeg MT et al. (2007) Molecular pathway for the localized formation of the sinoatrial node. Circ Res, 100:354-62. (PubMed:17234970)
  12. Pereira LA et al. (2011) Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity. PLoS One, 6:e28394. (PubMed:22164283)
  13. Pontecorvi M et al. (2008) Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis. Gene Expr Patterns, 8:411-7. (PubMed:18534921)
  14. Ribeiro I et al. (2007) Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling. PLoS ONE, 2:e398. (PubMed:17460765)
  15. Suzuki A et al. (2008) Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development, 135:1589-95. (PubMed:18356246)
  16. Wiese C et al. (2009) Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3. Circ Res, 104:388-97. (PubMed:19096026)
  17. Zirzow S et al. (2009) Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse. Dev Biol, 336:145-55. (PubMed:19769959)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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