About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
T
brachyury
MGI:98472

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of T. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Bogani D et al. (2004) New semidominant mutations that affect mouse development. Genesis, 40:109. (PubMed:15384171)
  2. David R et al. (2011) Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell. Cardiovasc Res, 92:115-22. (PubMed:21632880)
  3. Dietrich S et al. (1993) Altered Pax gene expression in murine notochord mutants: the notochord is required to initiate and maintain ventral identity in the somite. Mech Dev, 44:189-207. (PubMed:8155581)
  4. Harrison SM et al. (2000) Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with brachyury Dev Biol, 227:358-72. (PubMed:11071760)
  5. Inman KE et al. (2006) Brachyury is required for elongation and vasculogenesis in the murine allantois. Development, 133:2947-59. (PubMed:16835439)
  6. Johnson LR et al. (1995) Sperm from mice carrying one or two t haplotypes are deficient in investment and oocyte penetration. Dev Biol, 168:138-49. (PubMed:7883069)
  7. King T et al. (1998) The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev, 79:29-37. (PubMed:10349618)
  8. Kispert A et al. (1994) Immunohistochemical analysis of the Brachyury protein in wild-type and mutant mouse embryos. Dev Biol, 161:179-93. (PubMed:8293872)
  9. Kispert A et al. (1995) The T protein encoded by Brachyury is a tissue-specific transcription factor. EMBO J, 14:4763-72. (PubMed:7588606)
  10. Kispert A et al. (1993) The Brachyury gene encodes a novel DNA binding protein [published erratum appears in EMBO J 1993 Dec;12(12):4898-9] EMBO J, 12:3211-20. (PubMed:8344258)
  11. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
  12. Liu Y et al. (2007) Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells. Proc Natl Acad Sci U S A, 104:3859-64. (PubMed:17360443)
  13. Lyon MF et al. (1977) Derivation of mutant t-haplotypes of the mouse by presumed duplication or deletion. Genet Res, 30:63-76. (PubMed:924142)
  14. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  15. Pereira LA et al. (2011) Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity. PLoS One, 6:e28394. (PubMed:22164283)
  16. Rennebeck GM et al. (1995) Is there a Brachyury the Second? Analysis of a transgenic mutation involved in notochord maintenance in mice. Dev Biol, 172:206-17. (PubMed:7589801)
  17. Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev, 12:107-19. (PubMed:9420335)
  18. Suzuki A et al. (2006) Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A, 103:10294-9. (PubMed:16801560)
  19. Vidigal JA et al. (2010) An inducible RNA interference system for the functional dissection of mouse embryogenesis. Nucleic Acids Res, 38:e122. (PubMed:20350929)
  20. Wilson V et al. (1995) The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Development, 121:877-86. (PubMed:7720590)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory