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Gene Ontology Classifications
Symbol
Name
ID
Syn1
synapsin I
MGI:98460

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Syn1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
References
  1. Ahmad-Annuar A et al. (2006) Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release. J Cell Biol, 174:127-39. (PubMed:16818724)
  2. Ango F et al. (2004) Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. Cell, 119:257-72. (PubMed:15479642)
  3. Bamji SX et al. (2003) Role of beta-catenin in synaptic vesicle localization and presynaptic assembly. Neuron, 40:719-31. (PubMed:14622577)
  4. Gitler D et al. (2004) Molecular determinants of synapsin targeting to presynaptic terminals. J Neurosci, 24:3711-20. (PubMed:15071120)
  5. Holt M et al. (2006) Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression. J Biol Chem, 281:17076-83. (PubMed:16621800)
  6. Kuramochi-Miyagawa S et al. (2004) Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development, 131:839-49. (PubMed:14736746)
  7. Kuvbachieva A et al. (2004) Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. Eur J Neurosci, 20:603-10. (PubMed:15255972)
  8. Offenhauser N et al. (2006) Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics. Cell, 127:213-26. (PubMed:17018287)
  9. Rosahl TW et al. (1995) Essential functions of synapsins I and II in synaptic vesicle regulation [see comments] Nature, 375:488-93. (PubMed:7777057)
  10. Snyder EM et al. (2005) Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci, 8:1051-8. (PubMed:16025111)
  11. Spielhaupter C et al. (2001) PrPC Directly Interacts with Proteins Involved in Signaling Pathways. J Biol Chem, 276:44604-12. (PubMed:11571277)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory