Automated description from the Alliance of Genome Resources
Exhibits interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of cytokine production; and positive regulation of macrophage activation. Localizes to the external side of plasma membrane and extracellular matrix. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Is expressed in several structures, including immune system; musculoskeletal system; salivary gland; skin; and visual system. Orthologous to human IL1RL1 (interleukin 1 receptor like 1).