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Gene Ontology Classifications
SRY (sex determining region Y)-box 2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sox2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 11, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Ahmed M et al. (2012) EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear. Development, 139:1965-77. (PubMed:22513373)
  2. Andreu-Agullo C et al. (2012) Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2. Nature, 481:195-8. (PubMed:22198669)
  3. Avilion AA et al. (2003) Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev, 17:126-40. (PubMed:12514105)
  4. Baltus GA et al. (2009) A positive regulatory role for the mSin3A-HDAC complex in pluripotency through Nanog and Sox2. J Biol Chem, 284:6998-7006. (PubMed:19139101)
  5. Bani-Yaghoub M et al. (2006) Role of Sox2 in the development of the mouse neocortex. Dev Biol, 295:52-66. (PubMed:16631155)
  6. Botquin V et al. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev, 12:2073-90. (PubMed:9649510)
  7. Chew JL et al. (2005) Reciprocal Transcriptional Regulation of Pou5f1 and Sox2 via the Oct4/Sox2 Complex in Embryonic Stem Cells. Mol Cell Biol, 25:6031-46. (PubMed:15988017)
  8. Collignon J et al. (1996) A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2 Development, 122:509-20. (PubMed:8625802)
  9. Dong S et al. (2002) Circling, deafness, and yellow coat displayed by yellow submarine (ysb) and light coat and circling (lcc) mice with mutations on chromosome 3. Genomics, 79:777-84. (PubMed:12036291)
  10. Donner AL et al. (2007) Sox2 and Pou2f1 interact to control lens and olfactory placode development. Dev Biol, 303:784-799. (PubMed:17140559)
  11. Engelen E et al. (2011) Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet, 43:607-11. (PubMed:21532573)
  12. Fauquier T et al. (2008) SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland. Proc Natl Acad Sci U S A, 105:2907-12. (PubMed:18287078)
  13. Ferri AL et al. (2004) Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development, 131:3805-19. (PubMed:15240551)
  14. Gagliardi A et al. (2013) A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J, 32:2231-47. (PubMed:23892456)
  15. Gontan C et al. (2008) Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation. Dev Biol, 317:296-309. (PubMed:18374910)
  16. Haslinger A et al. (2009) Expression of Sox11 in adult neurogenic niches suggests a stage-specific role in adult neurogenesis. Eur J Neurosci, 29:2103-14. (PubMed:19490090)
  17. Ivanova N et al. (2006) Dissecting self-renewal in stem cells with RNA interference. Nature, 442:533-8. (PubMed:16767105)
  18. Iwafuchi-Doi M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development, 139:3926-37. (PubMed:22992956)
  19. Johansson H et al. (2010) Core transcription factors, Oct4, Sox2 and Nanog, individually form complexes with nucleophosmin (Npm1) to control embryonic stem (ES) cell fate determination. Aging (Albany NY), 2:815-22. (PubMed:21076177)
  20. Johnson LR et al. (1998) Role of the transcription factor Sox-2 in the expression of the FGF-4 gene in embryonal carcinoma cells. Mol Reprod Dev, 50:377-86. (PubMed:9669521)
  21. Kagey MH et al. (2010) Mediator and cohesin connect gene expression and chromatin architecture. Nature, 467:430-5. (PubMed:20720539)
  22. Kamachi Y et al. (1995) Involvement of SOX proteins in lens-specific activation of crystallin genes. EMBO J, 14:3510-9. (PubMed:7628452)
  23. Karantzali E et al. (2011) Sall1 regulates embryonic stem cell differentiation in association with nanog. J Biol Chem, 286:1037-45. (PubMed:21062744)
  24. Kelberman D et al. (2006) Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans. J Clin Invest, 116:2442-55. (PubMed:16932809)
  25. Kiernan AE et al. (2005) Sox2 is required for sensory organ development in the mammalian inner ear. Nature, 434:1031-5. (PubMed:15846349)
  26. Konno D et al. (2012) The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS One, 7:e46577. (PubMed:23056351)
  27. Krolewski RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS One, 7:e51737. (PubMed:23284756)
  28. Kunarso G et al. (2008) Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. BMC Genomics, 9:155. (PubMed:18400104)
  29. Li J et al. (2007) A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells. J Biol Chem, 282:19481-92. (PubMed:17507372)
  30. Li L et al. (2012) Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm. FEBS Lett, 586:4100-7. (PubMed:23108051)
  31. Li W et al. (2015) Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. Proc Natl Acad Sci U S A, 112:166-71. (PubMed:25535395)
  32. Li Y et al. (2012) Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells, 30:741-52. (PubMed:22232070)
  33. Mansukhani A et al. (2005) Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation. J Cell Biol, 168:1065-76. (PubMed:15781477)
  34. Maruyama M et al. (2005) Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem, 280:24371-9. (PubMed:15863505)
  35. Murakami A et al. (2004) SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J Biol Chem, 279:28564-73. (PubMed:15082719)
  36. Ng CK et al. (2012) Deciphering the Sox-Oct partner code by quantitative cooperativity measurements. Nucleic Acids Res, 40:4933-41. (PubMed:22344693)
  37. Niakan KK et al. (2010) Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev, 24:312-26. (PubMed:20123909)
  38. Nishiguchi S et al. (1998) Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev, 12:776-81. (PubMed:9512512)
  39. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  40. Okubo T et al. (2006) Sox2 is required for development of taste bud sensory cells. Genes Dev, 20:2654-9. (PubMed:17015430)
  41. Palasingam P et al. (2009) The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J Mol Biol, 388:619-30. (PubMed:19328208)
  42. Payer B et al. (2013) Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell, 52:805-18. (PubMed:24268575)
  43. Que J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development, 134:2521-31. (PubMed:17522155)
  44. Rockich BE et al. (2013) Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A, 110:E4456-64. (PubMed:24191021)
  45. Shimozaki K et al. (2013) Paired related homeobox protein 1 is a regulator of stemness in adult neural stem/progenitor cells. J Neurosci, 33:4066-75. (PubMed:23447615)
  46. Shiwaku H et al. (2010) Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. EMBO J, 29:2446-60. (PubMed:20531390)
  47. Sinner D et al. (2007) Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol, 27:7802-15. (PubMed:17875931)
  48. Taranova OV et al. (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev, 20:1187-202. (PubMed:16651659)
  49. Tokuzawa Y et al. (2003) Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol, 23:2699-708. (PubMed:12665572)
  50. Tomihara-Newberger C et al. (1998) The amn gene product is required in extraembryonic tissues for the generation of middle primitive streak derivatives. Dev Biol, 204:34-54. (PubMed:9851841)
  51. Tsuruzoe S et al. (2006) Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun, 351:920-6. (PubMed:17097055)
  52. van den Berg DL et al. (2010) An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell, 6:369-81. (PubMed:20362541)
  53. Wei Z et al. (2009) Klf4 interacts directly with Oct4 and Sox2 to promote reprogramming. Stem Cells, 27:2969-78. (PubMed:19816951)
  54. Yu HB et al. (2009) Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem, 284:31327-35. (PubMed:19740739)
  55. Yuan H et al. (1995) Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev, 9:2635-45. (PubMed:7590241)
  56. Zhang K et al. (2013) CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol, 383:15-27. (PubMed:24036311)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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