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Gene Ontology Classifications
Symbol
Name
ID
Ski
ski sarcoma viral oncogene homolog (avian)
MGI:98310

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ski. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 18, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
References
  1. Atanasoski S et al. (2004) The protooncogene Ski controls Schwann cell proliferation and myelination. Neuron, 43:499-511. (PubMed:15312649)
  2. Berk M et al. (1997) Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes Dev, 11:2029-39. (PubMed:9284043)
  3. Colmenares C et al. (2002) Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice. Nat Genet, 30:106-9. (PubMed:11731796)
  4. Dai P et al. (2002) Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3. Genes Dev, 16:2843-8. (PubMed:12435627)
  5. Deneault E et al. (2009) A functional screen to identify novel effectors of hematopoietic stem cell activity. Cell, 137:369-79. (PubMed:19379700)
  6. Engert JC et al. (1995) Activation of a muscle-specific enhancer by the Ski proto-oncogene. Nucleic Acids Res, 23:2988-94. (PubMed:7659522)
  7. Kobayashi N et al. (2007) c-Ski activates MyoD in the nucleus of myoblastic cells through suppression of histone deacetylases. Genes Cells, 12:375-85. (PubMed:17352741)
  8. Leferovich JM et al. (1995) Regulation of c-ski transgene expression in developing and mature mice. J Neurosci, 15:596-603. (PubMed:7823166)
  9. McGannon P et al. (2006) Ocular abnormalities in mice lacking the Ski proto-oncogene. Invest Ophthalmol Vis Sci, 47:4231-7. (PubMed:17003410)
  10. Shinagawa T et al. (2001) Increased susceptibility to tumorigenesis of ski-deficient heterozygous mice. Oncogene, 20:8100-8. (PubMed:11781823)
  11. Wang B et al. (2011) Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development, 138:4487-97. (PubMed:21937600)
  12. Zhang H et al. (2009) Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3. J Biol Chem, 284:2867-79. (PubMed:19008232)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory