Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Shc1. (This text reflects annotations as of Tuesday, May 21, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Shc1 has been shown to bind to the gene products of Amd1, Inppl1, Shcbp1. ^{[1, 4]} Researchers have inferred, based on physical interactions, that the gene product of Shc1
  • performs the following molecular functions:
    • ephrin receptor binding ^[5]
    • receptor tyrosine kinase binding ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Shc1
  • participates in the following biological processes:
    • actin cytoskeleton reorganization ^[2]
    • activation of MAPK activity ^[2]
    • angiogenesis ^[2]
    • cell-cell adhesion ^[2]
    • heart development ^[2]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Shc1:
  • participates in the following biological processes:
    • actin cytoskeleton organization
    • activation of MAPK activity
    • aging
    • insulin receptor signaling pathway
    • MAPK cascade
    • neuron differentiation
    • neuron projection development
    • positive regulation of DNA replication
    • positive regulation of smooth muscle cell proliferation
    • positive regulation of vasoconstriction
  • performs the following molecular functions:
    • ephrin receptor binding
    • epidermal growth factor receptor binding
    • insulin receptor binding
    • insulin-like growth factor receptor binding
    • neurotrophin TRKA receptor binding
    • phosphoprotein binding
    • phosphotyrosine binding
    • protein complex binding
    • receptor tyrosine kinase binding
  • is located in the following cellular components:
    • cytoplasm
    • endosome membrane
    • nucleus
    • plasma membrane
    • Shc-EGFR complex

---

Summary text based on GO annotations supported by structural data

• Shc1 encodes a protein or proteins that contain the following InterPro domains: Phosphotyrosine interaction (PID/PI), Phosphotyrosine interaction domain, Pleckstrin homology-like domain, SH2 domain, indicating that the gene product:
  • participates in the following biological processes:
    • intracellular signal transduction

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Shc1 indicates that it:
  • participates in the following biological processes:
    • regulation of growth
  • is located in the following cellular components:
    • mitochondrion

---

References

1. Gagnon A et al. (2003) Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. J Cell Physiol, 197:243-50. (PubMed:14502564)
2. Lai KM et al. (2000) The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev, 14:1132-45. (PubMed:10809671)
3. Minichiello L et al. (2002) Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron, 36:121-37. (PubMed:12367511)
4. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
5. Vindis C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol, 162:661-71. (PubMed:12925710)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---