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Gene Ontology Classifications
Symbol
Name
ID
Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296

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GO curators for mouse genes have assigned the following annotations to the gene product of Shc1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Findlay GM et al. (2013) Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell, 152:1008-20. (PubMed:23452850)
  2. Gagnon A et al. (2003) Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes. J Cell Physiol, 197:243-50. (PubMed:14502564)
  3. Lai KM et al. (2000) The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev, 14:1132-45. (PubMed:10809671)
  4. Lee MK et al. (2007) TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J, 26:3957-67. (PubMed:17673906)
  5. Minichiello L et al. (2002) Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron, 36:121-37. (PubMed:12367511)
  6. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  7. Poe JC et al. (2000) CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. J Biol Chem, 275:17420-7. (PubMed:10748054)
  8. Ravichandran KS et al. (1995) Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol Cell Biol, 15:593-600. (PubMed:7529871)
  9. Smith MJ et al. (2010) The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1. EMBO J, 29:884-96. (PubMed:20075861)
  10. Ursini-Siegel J et al. (2008) ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J, 27:910-20. (PubMed:18273058)
  11. VanderKuur J et al. (1995) Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2. J Biol Chem, 270:7587-93. (PubMed:7535773)
  12. Vindis C et al. (2003) EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J Cell Biol, 162:661-71. (PubMed:12925710)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory