Gene Ontology Classifications

Symbol
Name
ID

Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296

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Automated description from the Alliance of Genome Resources (Release 9.0.0)

Enables epidermal growth factor binding activity; identical protein binding activity; and signaling receptor binding activity. Involved in B cell receptor signaling pathway; insulin receptor signaling pathway; and insulin-like growth factor receptor signaling pathway. Acts upstream of or within several processes, including circulatory system development; epidermal growth factor receptor signaling pathway; and positive regulation of MAPK cascade. Predicted to be located in cytosol and endosome membrane. Predicted to be part of Shc-EGFR complex. Predicted to be active in plasma membrane. Is expressed in several structures, including 8-cell stage conceptus; blastocyst-stage conceptus; cerebral cortex; early embryo; and skin. Orthologous to human SHC1 (SHC adaptor protein 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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