Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Msr1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Msr1
  • participates in the following biological processes:
    • cholesterol transport ^[1]
    • lipoprotein transport ^[2]
    • plasma lipoprotein particle clearance ^[1]
    • positive regulation of cholesterol storage ^[1]
  • performs the following molecular functions:
    • low-density lipoprotein particle binding ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Msr1
  • participates in the following biological processes:
    • positive regulation of macrophage derived foam cell differentiation based on interactions with Cd36 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Msr1:
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • cytosol
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Msr1 encodes a protein or proteins that contain the following InterPro domains: Collagen triple helix repeat, Macrophage scavenger receptor, Speract/scavenger receptor, Speract/scavenger receptor-related, indicating that the gene product:
  • participates in the following biological processes:
    • receptor-mediated endocytosis
  • performs the following molecular functions:
    • scavenger receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Msr1 indicates that it:
  • participates in the following biological processes:
    • endocytosis
  • is located in the following cellular components:
    • collagen
    • integral to membrane
    • low-density lipoprotein particle
    • membrane

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References

1. Kunjathoor VV et al. (2002) Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem, 277:49982-8. (PubMed:12376530)
2. Wang MD et al. (2007) Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res, 48:633-45. (PubMed:17148552)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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