Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Scn3a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Scn3a
  • is located in the following cellular components:
    • cytoplasm ^[1]
    • membrane ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Scn3a:
  • participates in the following biological processes:
    • cellular response to antibiotic
    • regulation of action potential in neuron
    • response to pyrethroid
    • sensory perception of pain
    • sodium ion transmembrane transport
  • performs the following molecular functions:
    • calmodulin binding
    • sodium ion binding
    • voltage-gated sodium channel activity
  • is located in the following cellular components:
    • axon
    • neuronal cell body
    • voltage-gated sodium channel complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Scn3a indicates that it:
  • participates in the following biological processes:
    • ion transmembrane transport
    • ion transport
    • potassium ion transmembrane transport
    • potassium ion transport
    • regulation of ion transmembrane transport
    • sodium ion transmembrane transport
    • sodium ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • potassium channel activity
    • sodium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Haufe V et al. (2005) Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J Physiol, 564:683-96. (PubMed:15746173)
2. Ogiwara I et al. (2007) Na(v)1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. J Neurosci, 27:5903-14. (PubMed:17537961)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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