Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits voltage-gated sodium channel activity. Involved in several processes, including adult walking behavior; detection of mechanical stimulus involved in sensory perception of pain; and neuronal action potential. Localizes to several cellular components, including T-tubule; Z disc; and main axon. Is expressed in brain; heart; sciatic nerve; sympathetic ganglion; and telencephalon. Used to study Dravet syndrome; autism spectrum disorder; and generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in Dravet syndrome; familial hemiplegic migraine 3; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Orthologous to human SCN1A (sodium voltage-gated channel alpha subunit 1).