Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Sat1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on genetic interactions, that the gene product of Sat1
  • participates in the following biological processes:
    • regulation of cell proliferation based on interactions with Apc ^{[1, 2]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Sat1:
  • participates in the following biological processes:
    • polyamine metabolic process
  • performs the following molecular functions:
    • N-acetyltransferase activity
    • spermidine binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Sat1 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • cytoplasm
• Sat1 has been associated with the Enzyme Commission numbers: 2.3.1.57, which implies that the gene product:
  • performs the following molecular functions:
    • diamine N-acetyltransferase activity

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References

1. Berger FG et al. (2007) Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse. Biochem Soc Trans, 35:336-9. (PubMed:17371273)
2. Tucker JM et al. (2005) Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase. Cancer Res, 65:5390-8. (PubMed:15958588)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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