Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Saa1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Saa1
  • participates in the following biological processes:
    • cholesterol metabolic process ^[2]
  • is located in the following cellular components:
    • extracellular space ^[2]
• The gene product of Saa1 has been shown to bind to the gene products of Lama1. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Saa1:
  • performs the following molecular functions:
    • G-protein coupled receptor binding
  • is located in the following cellular components:
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• Saa1 encodes a protein or proteins that contain the following InterPro domains: Serum amyloid A protein, indicating that the gene product:
  • participates in the following biological processes:
    • acute-phase response
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Saa1 indicates that it:
  • participates in the following biological processes:
    • acute-phase response
  • performs the following molecular functions:
    • heparin binding
  • is located in the following cellular components:
    • extracellular region
    • high-density lipoprotein particle

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References

1. Ancsin JB et al. (1997) Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A. J Biol Chem, 272:406-13. (PubMed:8995276)
2. Webb NR et al. (1997) Adenoviral vector-mediated overexpression of serum amyloid A in apoA-I-deficient mice. J Lipid Res, 38:1583-90. (PubMed:9300780)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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