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Gene Ontology Classifications
retinoid X receptor alpha

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GO curators for mouse genes have assigned the following annotations to the gene product of Rxra. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bajpe PK et al. (2013) The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling. Mol Cell Biol, 33:3343-53. (PubMed:23775127)
  2. Bartholin L et al. (2006) TGIF inhibits retinoid signaling. Mol Cell Biol, 26:990-1001. (PubMed:16428452)
  3. Ben-Shushan E et al. (1995) A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol Cell Biol, 15:1034-48. (PubMed:7823919)
  4. Brocard J et al. (1996) Two novel RXR alpha isoforms from mouse testis. Biochem Biophys Res Commun, 229:211-8. (PubMed:8954108)
  5. Cha JY et al. (2007) The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem, 282:743-51. (PubMed:17107947)
  6. Chen J et al. (1998) Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development, 125:1943-9. (PubMed:9550726)
  7. Cho YS et al. (2006) Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor. J Biol Chem, 281:17588-98. (PubMed:16606617)
  8. Compe E et al. (2007) Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH. Nat Neurosci, 10:1414-22. (PubMed:17952069)
  9. Guan HP et al. (2005) Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev, 19:453-61. (PubMed:15681609)
  10. Helledie T et al. (2002) The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. J Biol Chem, 277:26821-30. (PubMed:12015306)
  11. Huang J et al. (2002) Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. Cancer Res, 62:4812-9. (PubMed:12183441)
  12. Huang N et al. (1998) Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators. EMBO J, 17:3398-412. (PubMed:9628876)
  13. Kabe Y et al. (2005) NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes. Mol Cell Biol, 25:512-22. (PubMed:15601870)
  14. Kastner P et al. (1997) Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes. Development, 124:4749-58. (PubMed:9428411)
  15. Khetchoumian K et al. (2004) TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. J Biol Chem, 279:48329-41. (PubMed:15322135)
  16. Le Douarin B et al. (1996) A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J, 15:6701-15. (PubMed:8978696)
  17. LeDouarin B et al. (1995) The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J, 14:2020-33. (PubMed:7744009)
  18. Lee HK et al. (2007) MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J, 26:3545-57. (PubMed:17641689)
  19. Lim H et al. (1999) Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta. Genes Dev, 13:1561-74. (PubMed:10385625)
  20. Makita T et al. (2005) Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol, 280:59-72. (PubMed:15766748)
  21. Malik S et al. (2004) Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol, 24:8244-54. (PubMed:15340084)
  22. Mangelsdorf DJ et al. (1992) Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev, 6:329-44. (PubMed:1312497)
  23. Mathur M et al. (2001) PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors. Mol Cell Biol, 21:2298-311. (PubMed:11259580)
  24. Nakamura K et al. (2004) Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J Biol Chem, 279:45980-9. (PubMed:15319426)
  25. Pei L et al. (2011) Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome. Nat Med, 17:1466-72. (PubMed:22001906)
  26. Rajakumari S et al. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metab, 17:562-74. (PubMed:23499423)
  27. Sapin V et al. (1997) Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses. Dev Biol, 191:29-41. (PubMed:9356169)
  28. Seol W et al. (1995) Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol, 9:72-85. (PubMed:7760852)
  29. Song KH et al. (2003) Molecular cloning and characterization of a novel inhibitor of apoptosis protein from Xenopus laevis. Biochem Biophys Res Commun, 301:236-42. (PubMed:12535669)
  30. Subbarayan V et al. (1997) Limited specificity and large overlap of the functions of the mouse RAR gamma 1 and RAR gamma 2 isoforms. Mech Dev, 66:131-42. (PubMed:9376317)
  31. vom Baur E et al. (1996) Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. EMBO J, 15:110-24. (PubMed:8598193)
  32. Wendling O et al. (1999) Retinoid X receptors are essential for early mouse development and placentogenesis. Proc Natl Acad Sci U S A, 96:547-51. (PubMed:9892670)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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