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Gene Ontology Classifications
ret proto-oncogene

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GO curators for mouse genes have assigned the following annotations to the gene product of Ret. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Baloh RH et al. (1998) GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc Natl Acad Sci U S A, 95:5801-6. (PubMed:9576965)
  2. Batourina E et al. (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet, 32:109-15. (PubMed:12195422)
  3. Bolon B et al. (2004) The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction. Toxicol Pathol, 32:275-94. (PubMed:15204970)
  4. Bonanomi D et al. (2012) Ret Is a Multifunctional Coreceptor that Integrates Diffusible- and Contact-Axon Guidance Signals. Cell, 148:568-82. (PubMed:22304922)
  5. Burau K et al. (2004) c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Eur J Neurosci, 20:353-62. (PubMed:15233745)
  6. Cabrera JR et al. (2011) RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons. J Biol Chem, 286:14628-38. (PubMed:21357690)
  7. Chia I et al. (2011) Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development, 138:2089-97. (PubMed:21521737)
  8. Clarke JC et al. (2006) Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage. Hum Mol Genet, 15:3420-8. (PubMed:17047028)
  9. Evangelisti C et al. (2012) Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathways. Neurogastroenterol Motil, 24:e497-508. (PubMed:22897442)
  10. Golden JP et al. (2010) RET signaling is required for survival and normal function of nonpeptidergic nociceptors. J Neurosci, 30:3983-94. (PubMed:20237269)
  11. Luo W et al. (2007) A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons. Neuron, 54:739-54. (PubMed:17553423)
  12. Natarajan D et al. (1999) Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development, 126:157-68. (PubMed:9834195)
  13. Rossi J et al. (2000) Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo. Eur J Neurosci, 12:3944-52. (PubMed:11069590)
  14. Schuetz G et al. (2004) The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells. J Cell Biol, 167:945-52. (PubMed:15569713)
  15. Veiga-Fernandes H et al. (2007) Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis. Nature, 446:547-51. (PubMed:17322904)
  16. Worby CA et al. (1998) Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J Biol Chem, 273:3502-8. (PubMed:9452475)
  17. Yan H et al. (2004) Neural cells in the esophagus respond to glial cell line-derived neurotrophic factor and neurturin, and are RET-dependent. Dev Biol, 272:118-33. (PubMed:15242795)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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