Automated description from the Alliance of Genome Resources (Release 4.0)
Exhibits transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to localize to several cellular components, including endosome; membrane raft; and neuronal cell body. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene).