Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ren1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ren1
  • participates in the following biological processes:
    • hormone-mediated signaling pathway ^[3]
    • renin-angiotensin regulation of aldosterone production ^[1]
    • response to organic substance ^[1]
  • performs the following molecular functions:
    • endopeptidase activity ^[1]
  • is located in the following cellular components:
    • extracellular space ^{[1, 2]}
    • intracellular ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ren1
  • participates in the following biological processes:
    • angiotensin maturation ^[4]
    • cell maturation ^[4]
    • drinking behavior ^[4]
    • regulation of blood volume by renin-angiotensin ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ren1:
  • participates in the following biological processes:
    • angiotensin maturation
    • kidney development
    • proteolysis
    • regulation of blood pressure
    • regulation of MAPK cascade
    • response to cAMP
    • response to cGMP
    • response to drug
    • response to stress
  • performs the following molecular functions:
    • aspartic-type endopeptidase activity
    • endopeptidase activity
    • insulin-like growth factor receptor binding
    • peptidase activity
    • receptor binding
  • is located in the following cellular components:
    • cytoplasmic part
    • extracellular space

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ren1 indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
  • is located in the following cellular components:
    • extracellular region
    • membrane

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References

1. Fowler JD et al. (2009) Regulated renin release from 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab, 296:E1383-91. (PubMed:19293336)
2. Kim HS et al. (1999) Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem, 274:14210-7. (PubMed:10318840)
3. Klar J et al. (2004) Aldosterone enhances renin gene expression in juxtaglomerular cells. Am J Physiol Renal Physiol, 286:F349-55. (PubMed:14583438)
4. Yanai K et al. (2000) Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J Biol Chem, 275:5-8. (PubMed:10617578)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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