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Gene Ontology Classifications
RAD51 homolog

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rad51. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Akamatsu Y et al. (2010) Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PLoS Genet, 6:e1001160. (PubMed:20976249)
  2. Berkowitz KM et al. (2012) Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet, 8:e1002996. (PubMed:23133398)
  3. Cherry SM et al. (2007) The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. Curr Biol, 17:373-8. (PubMed:17291760)
  4. Gudmundsdottir K et al. (2004) DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep, 5:989-93. (PubMed:15359272)
  5. Guiraldelli MF et al. (2013) Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis. PLoS Genet, 9:e1003383. (PubMed:23555294)
  6. Herran Y et al. (2011) The cohesin subunit RAD21L functions in meiotic synapsis and exhibits sexual dimorphism in fertility. EMBO J, 30:3091-105. (PubMed:21743440)
  7. Holloway JK et al. (2014) Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol, 205:633-41. (PubMed:24891606)
  8. Houghtaling S et al. (2003) Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev, 17:2021-35. (PubMed:12893777)
  9. Kim TM et al. (2012) RAD51 mutants cause replication defects and chromosomal instability. Mol Cell Biol, 32:3663-80. (PubMed:22778135)
  10. Kneitz B et al. (2000) MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev, 14:1085-97. (PubMed:10809667)
  11. Kogo H et al. (2012) HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes. Genes Cells, 17:439-54. (PubMed:22530760)
  12. Kouznetsova A et al. (2011) Meiosis in mice without a synaptonemal complex. PLoS One, 6:e28255. (PubMed:22164254)
  13. Kumar R et al. (2010) Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev, 24:1266-80. (PubMed:20551173)
  14. Kwan KY et al. (2003) Infertility and aneuploidy in mice lacking a type IA DNA topoisomerase III beta. Proc Natl Acad Sci U S A, 100:2526-31. (PubMed:12591952)
  15. Li MJ et al. (1996) Rad51 expression and localization in B cells carrying out class switch recombination. Proc Natl Acad Sci U S A, 93:10222-7. (PubMed:8816780)
  16. Libby BJ et al. (2003) Positional cloning and characterization of Mei1, a vertebrate-specific gene required for normal meiotic chromosome synapsis in mice. Proc Natl Acad Sci U S A, 100:15706-11. (PubMed:14668445)
  17. Lipkin SM et al. (2002) Meiotic arrest and aneuploidy in MLH3-deficient mice. Nat Genet, 31:385-90. (PubMed:12091911)
  18. Sarkisian CJ et al. (2001) Analysis of murine brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals. J Biol Chem, 276:37640-8. (PubMed:11477095)
  19. Sharan SK et al. (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments] Nature, 386:804-10. (PubMed:9126738)
  20. Simandlova J et al. (2013) FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. J Biol Chem, 288:34168-80. (PubMed:24108124)
  21. Soper SF et al. (2008) Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. Dev Cell, 15:285-97. (PubMed:18694567)
  22. Stark JM et al. (2004) Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol Cell Biol, 24:9305-16. (PubMed:15485900)
  23. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)
  24. Wong JC et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet, 12:2063-76. (PubMed:12913077)
  25. Yang F et al. (2008) Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol, 180:673-9. (PubMed:18283110)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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