Automated description from the Alliance of Genome Resources
Exhibits RNA polymerase II activating transcription factor binding activity and enzyme binding activity. Involved in several processes, including negative regulation of cell cycle; neuron development; and regulation of transcription, DNA-templated. Localizes to the Rb-E2F complex and spindle. Predicted to colocalize with the cyclin/CDK positive transcription elongation factor complex. Human ortholog(s) of this gene implicated in several diseases, including malignant glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system; retina; and vibrissa. Orthologous to human RB1 (RB transcriptional corepressor 1).