Automated description from the Alliance of Genome Resources
Exhibits several functions, including protein homodimerization activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to contribute to double-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including immune system development; negative regulation of apoptotic process; and protein ubiquitination. Localizes to the nucleus. Human ortholog(s) of this gene implicated in Omenn syndrome; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, Nk cell-positive. Is expressed in several structures, including arterial system; genitourinary system; gut; hemolymphoid system; and mesenchyme derived from splanchnopleure. Orthologous to human RAG1 (recombination activating 1).