Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rab1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Rab1
  • is located in the following cellular components:
    • Golgi apparatus ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rab1:
  • participates in the following biological processes:
    • ER to Golgi vesicle-mediated transport
  • performs the following molecular functions:
    • GTP binding
  • is located in the following cellular components:
    • endoplasmic reticulum membrane
    • Golgi membrane
    • neuronal cell body

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Summary text based on GO annotations supported by structural data

• Rab1 encodes a protein or proteins that contain the following InterPro domains: Small GTP-binding protein domain, Small GTPase superfamily, Small GTPase superfamily, Rab type, indicating that the gene product:
  • participates in the following biological processes:
    • protein transport
    • small GTPase mediated signal transduction

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rab1 indicates that it:
  • participates in the following biological processes:
    • protein transport
    • transport
    • vesicle-mediated transport
  • performs the following molecular functions:
    • nucleotide binding
  • is located in the following cellular components:
    • endoplasmic reticulum

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References

1. Bell AW et al. (2001) Proteomics characterization of abundant Golgi membrane proteins. J Biol Chem, 276:5152-65. (PubMed:11042173)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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