Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pth1r. (This text reflects annotations as of Wednesday, August 14, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pth1r
  • is located in the following cellular components:
    • intracellular ^[6]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Pth1r
  • participates in the following biological processes:
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway ^[4]
    • bone mineralization ^{[3, 4]}
    • bone resorption ^[4]
    • cell maturation ^[2]
    • cellular calcium ion homeostasis ^[4]
    • chondrocyte differentiation ^[4]
    • negative regulation of cell proliferation ^[2]
    • ossification ^[2]
    • osteoblast development ^[4]
    • phospholipase C-activating G-protein coupled receptor signaling pathway ^[2]
    • skeletal system development ^{[3, 5]}
  • performs the following molecular functions:
    • parathyroid hormone receptor activity ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Pth1r
  • participates in the following biological processes:
    • chondrocyte differentiation based on interactions with Runx2 ^[1]
    • positive regulation of cell proliferation based on interactions with Runx2 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pth1r:
  • participates in the following biological processes:
    • adenylate cyclase-activating G-protein coupled receptor signaling pathway
    • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
    • elevation of cytosolic calcium ion concentration
    • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
    • phospholipase C-activating G-protein coupled receptor signaling pathway
    • positive regulation of inositol phosphate biosynthetic process
  • performs the following molecular functions:
    • parathyroid hormone receptor activity
    • peptide hormone binding
    • protein self-association
  • is located in the following cellular components:
    • apical plasma membrane
    • basolateral plasma membrane
    • brush border membrane
    • cytoplasm
    • integral to plasma membrane
    • nucleus
    • plasma membrane
    • receptor complex

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Summary text based on GO annotations supported by structural data

• Pth1r encodes a protein or proteins that contain the following InterPro domains: GPCR, family 2, extracellular hormone receptor domain, GPCR, family 2, parathyroid hormone receptor, GPCR, family 2, secretin-like, GPCR, family 2, secretin-like, conserved site, GPCR, family 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pth1r indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Guo J et al. (2006) PTH/PTHrP receptor delays chondrocyte hypertrophy via both Runx2-dependent and -independent pathways. Dev Biol, 292:116-28. (PubMed:16476422)
2. Guo J et al. (2002) The PTH/PTHrP receptor can delay chondrocyte hypertrophy in vivo without activating phospholipase C. Dev Cell, 3:183-94. (PubMed:12194850)
3. Kovacs CS et al. (2001) Pth regulates fetal blood calcium and skeletal mineralization independently of pthrp. Endocrinology, 142:4983-93. (PubMed:11606467)
4. Lanske B et al. (1998) The parathyroid hormone (PTH)/PTH-related peptide receptor mediates actions of both ligands in murine bone. Endocrinology, 139:5194-204. (PubMed:9832460)
5. Lanske B et al. (1996) PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth [see comments] Science, 273:663-6. (PubMed:8662561)
6. Lee K et al. (1996) Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development. Endocrinology, 137:5109-18. (PubMed:8895385)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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