Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ptgs1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ptgs1
  • is located in the following cellular components:
    • cytoplasm ^[3]
    • cytoplasmic part ^[2]
    • photoreceptor outer segment ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ptgs1
  • participates in the following biological processes:
    • prostaglandin biosynthetic process ^[4]
    • prostaglandin metabolic process ^[1]
    • regulation of blood pressure ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Ptgs1
  • participates in the following biological processes:
    • regulation of cell proliferation based on interactions with Apc ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ptgs1:
  • participates in the following biological processes:
    • cyclooxygenase pathway
    • learning
    • maintenance of blood-brain barrier
    • memory
    • negative regulation of epinephrine secretion
    • negative regulation of norepinephrine secretion
    • oxidation-reduction process
    • positive regulation of smooth muscle contraction
    • positive regulation of vasoconstriction
    • prostaglandin biosynthetic process
    • sensory perception of pain
  • performs the following molecular functions:
    • lipid binding
    • prostaglandin-endoperoxide synthase activity
  • is located in the following cellular components:
    • cytoplasm
    • cytoplasmic part
    • nuclear envelope

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Summary text based on GO annotations supported by structural data

• Ptgs1 encodes a protein or proteins that contain the following InterPro domains: Epidermal growth factor-like domain, Haem peroxidase, Haem peroxidase, animal, Haem peroxidase, animal, subgroup, indicating that the gene product:
  • participates in the following biological processes:
    • response to oxidative stress
  • performs the following molecular functions:
    • heme binding
    • peroxidase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ptgs1 indicates that it:
  • participates in the following biological processes:
    • fatty acid biosynthetic process
    • fatty acid metabolic process
    • lipid metabolic process
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
    • oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
    • peroxidase activity
  • is located in the following cellular components:
    • endoplasmic reticulum
    • intracellular membrane-bounded organelle
    • membrane

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References

1. Chulada PC et al. (2000) Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res, 60:4705-8. (PubMed:10987272)
2. Ju WK et al. (2002) Cellular localization of cyclooxygenase-1 and cyclooxygenase-2 in the normal mouse, rat, and human retina. J Comp Neurol, 452:392-9. (PubMed:12355421)
3. Lazarus M et al. (2002) Immunohistochemical localization of microsomal PGE synthase-1 and cyclooxygenases in male mouse reproductive organs. Endocrinology, 143:2410-9. (PubMed:12021206)
4. Qi Z et al. (2002) Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J Clin Invest, 110:61-9. (PubMed:12093889)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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