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Gene Ontology Classifications
Symbol
Name
ID
Prph
peripherin
MGI:97774

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Prph. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
References
  1. Faussone-Pellegrini MS et al. (1999) The cytoskeleton of the myenteric neurons during murine embryonic life. Anat Embryol (Berl), 199:459-69. (PubMed:10221457)
  2. Hagstrom SA et al. (2012) Tulp1 is involved in specific photoreceptor protein transport pathways. Adv Exp Med Biol, 723:783-9. (PubMed:22183407)
  3. Liu X et al. (1999) Myosin VIIa participates in opsin transport through the photoreceptor cilium. J Neurosci, 19:6267-74. (PubMed:10414956)
  4. Loes S et al. (2002) Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers. Anat Embryol (Berl), 205:187-91. (PubMed:12107488)
  5. Murthy M et al. (2014) Transcription factor Runx1 inhibits proliferation and promotes developmental maturation in a selected population of inner olfactory nerve layer olfactory ensheathing cells. Gene, 540:191-200. (PubMed:24582971)
  6. Rao MV et al. (2002) Myosin Va binding to neurofilaments is essential for correct myosin Va distribution and transport and neurofilament density. J Cell Biol, 159:279-90. (PubMed:12403814)
  7. Robertson J et al. (2003) A neurotoxic peripherin splice variant in a mouse model of ALS. J Cell Biol, 160:939-49. (PubMed:12642616)
  8. Rush AM et al. (2005) Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci, 22:39-49. (PubMed:16029194)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory