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Gene Ontology Classifications
Symbol
Name
ID
Prlr
prolactin receptor
MGI:97763

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Prlr. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Chan CB et al. (2010) PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J, 29:956-68. (PubMed:20075866)
  2. Harris J et al. (2006) Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol, 20:1177-87. (PubMed:16469767)
  3. Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology, 112:2032-8. (PubMed:6303755)
  4. Lindeman GJ et al. (2001) SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev, 15:1631-6. (PubMed:11445538)
  5. Miyoshi K et al. (2001) Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol, 155:531-42. (PubMed:11706048)
  6. Robertson FG et al. (2003) Prostate development and carcinogenesis in prolactin receptor knockout mice. Endocrinology, 144:3196-205. (PubMed:12810576)
  7. Shillingford JM et al. (2002) Mouse Mammary Epithelial Cells Express the Na-K-Cl Cotransporter, NKCC1: Characterization, Localization, and Involvement in Ductal Development and Morphogenesis. Mol Endocrinol, 16:1309-21. (PubMed:12040017)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory