Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Prlr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Prlr
  • participates in the following biological processes:
    • prolactin signaling pathway ^[3]
  • performs the following molecular functions:
    • prolactin receptor activity ^[3]
• The gene product of Prlr has been shown to bind to the gene products of Agap2, Stat5a. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Prlr
  • participates in the following biological processes:
    • JAK-STAT cascade ^[2]
    • lactation ^{[2, 5]}
    • mammary gland alveolus development ^[2]
    • mammary gland epithelium development ^[7]
    • prolactin signaling pathway ^[5]
    • prostate gland growth ^[6]
    • regulation of cell adhesion ^[5]
    • regulation of epithelial cell differentiation ^[5]
  • performs the following molecular functions:
    • prolactin receptor activity ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Prlr
  • participates in the following biological processes:
    • lactation based on interactions with Socs1 ^[4]
    • mammary gland alveolus development based on interactions with Socs1, Socs2 ^{[2, 4]}
    • mammary gland epithelial cell differentiation based on interactions with Elf5 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Prlr:
  • participates in the following biological processes:
    • activation of transmembrane receptor protein tyrosine kinase activity
    • prolactin signaling pathway
  • performs the following molecular functions:
    • peptide hormone binding
    • prolactin receptor activity
    • protein kinase binding
  • is located in the following cellular components:
    • cell surface

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Summary text based on GO annotations supported by structural data

• Prlr encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type III, Growth hormone/erythropoietin receptor, ligand binding, Immunoglobulin-like fold, Long hematopoietin receptor, single chain, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • cytokine-mediated signaling pathway
  • performs the following molecular functions:
    • cytokine receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Prlr indicates that it:
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Chan CB et al. (2010) PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J, 29:956-68. (PubMed:20075866)
2. Harris J et al. (2006) Socs2 and elf5 mediate prolactin-induced mammary gland development. Mol Endocrinol, 20:1177-87. (PubMed:16469767)
3. Herington AC et al. (1983) Hepatic binding of human and bovine growth hormones and ovine prolactin in the dwarf little mouse. Endocrinology, 112:2032-8. (PubMed:6303755)
4. Lindeman GJ et al. (2001) SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev, 15:1631-6. (PubMed:11445538)
5. Miyoshi K et al. (2001) Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol, 155:531-42. (PubMed:11706048)
6. Robertson FG et al. (2003) Prostate development and carcinogenesis in prolactin receptor knockout mice. Endocrinology, 144:3196-205. (PubMed:12810576)
7. Shillingford JM et al. (2002) Mouse Mammary Epithelial Cells Express the Na-K-Cl Cotransporter, NKCC1: Characterization, Localization, and Involvement in Ductal Development and Morphogenesis. Mol Endocrinol, 16:1309-21. (PubMed:12040017)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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