Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Plp1. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Plp1
  • is located in the following cellular components:
    • myelin sheath ^{[3, 5]}
• The gene product of Plp1 has been shown to bind to the gene products of Dusp6. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Plp1
  • participates in the following biological processes:
    • axon ensheathment ^[6]
    • cell maturation ^[7]
    • central nervous system myelination ^[3]
    • long-chain fatty acid biosynthetic process ^[4]
    • myelination ^{[1, 4]}
    • positive regulation of gene expression ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Plp1:
  • participates in the following biological processes:
    • glial cell differentiation
    • integrin-mediated signaling pathway
    • myelination
  • performs the following molecular functions:
    • structural constituent of myelin sheath
    • structural molecule activity

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Summary text based on GO annotations supported by structural data

• Plp1 encodes a protein or proteins that contain the following InterPro domains: Myelin proteolipid protein PLP, Myelin proteolipid protein PLP, conserved site, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Plp1 indicates that it:
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Amiguet P et al. (1992) Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein. J Neurochem, 58:1676-82. (PubMed:1373175)
2. Castelli M et al. (2004) MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha. J Biol Chem, 279:44731-9. (PubMed:15284227)
3. Griffiths IR et al. (1990) Rumpshaker mouse: a new X-linked mutation affecting myelination: evidence for a defect in PLP expression. J Neurocytol, 19:273-83. (PubMed:1694232)
4. Murad S et al. (1975) Alpha hydroxylation of lignoceric acid to cerebronic acid during brain development. Diminished hydroxylase activity in myelin-deficient mouse mutants. J Biol Chem, 250:5841-6. (PubMed:1150661)
5. Parenti R et al. (2010) Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity. Glia, 58:1594-609. (PubMed:20578039)
6. SIDMAN RL et al. (1964) MUTANT MICE (QUAKING AND JIMPY) WITH DEFICIENT MYELINATION IN THE CENTRAL NERVOUS SYSTEM. Science, 144:309-11. (PubMed:14169723)
7. Sporkel O et al. (2002) Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development. Glia, 37:19-30. (PubMed:11746780)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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