About   Help   FAQ
Gene Ontology Classifications
phospholipase C, beta 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Plcb1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Avazeri N et al. (2003) Meiosis resumption, calcium-sensitive period, and PLC-beta1 relocation into the nucleus in the mouse oocyte. Cell Signal, 15:1003-10. (PubMed:14499343)
  2. Ballester M et al. (2004) Disruption of the mouse phospholipase C-beta1 gene in a beta-lactoglobulin transgenic line affects viability, growth, and fertility in mice. Gene, 341:279-89. (PubMed:15474310)
  3. Bavelloni A et al. (2006) Proteomic-based analysis of nuclear signaling: PLCbeta1 affects the expression of the splicing factor SRp20 in Friend erythroleukemia cells. Proteomics, 6:5725-34. (PubMed:17022104)
  4. Choi D et al. (2001) The biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo development. J Assist Reprod Genet, 18:305-10. (PubMed:11464583)
  5. Cocco L et al. (1998) Inositides in the nucleus: taking stock of PLC beta 1. Adv Enzyme Regul, 38:351-63. (PubMed:9762362)
  6. Faenza I et al. (2004) Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation. J Cell Physiol, 200:291-6. (PubMed:15174099)
  7. Faenza I et al. (2002) Nuclear PLCbeta(1) acts as a negative regulator of p45/NF-E2 expression levels in Friend erythroleukemia cells. Biochim Biophys Acta, 1589:305-10. (PubMed:12031797)
  8. Faenza I et al. (2000) A role for nuclear phospholipase Cbeta 1 in cell cycle control. J Biol Chem, 275:30520-4. (PubMed:10913438)
  9. Fiume R et al. (2005) Nuclear phospholipase C beta1 (PLCbeta1) affects CD24 expression in murine erythroleukemia cells. J Biol Chem, 280:24221-6. (PubMed:15849202)
  10. Fiume R et al. (2009) Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression. FASEB J, 23:957-66. (PubMed:19028838)
  11. Hannan AJ et al. (2001) PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Nat Neurosci, 4:282-8. (PubMed:11224545)
  12. Kim D et al. (1997) Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature, 389:290-3. (PubMed:9305844)
  13. Lefevre B et al. (2007) The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyte. Crit Rev Eukaryot Gene Expr, 17:259-69. (PubMed:17725492)
  14. Manzoli L et al. (1997) Essential role for nuclear phospholipase C beta1 in insulin-like growth factor I-induced mitogenesis. Cancer Res, 57:2137-9. (PubMed:9187110)
  15. McOmish CE et al. (2008) PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression. Hippocampus, 18:824-34. (PubMed:18493969)
  16. O'Carroll SJ et al. (2009) Nuclear PLCbeta1 is required for 3T3-L1 adipocyte differentiation and regulates expression of the cyclin D3-cdk4 complex. Cell Signal, 21:926-35. (PubMed:19385066)
  17. Rudnicka W et al. (1997) The host response to Listeria monocytogenes mutants defective in genes encoding phospholipases C (plcA, plcB) and actin assembly (actA). Microbiol Immunol, 41:847-53. (PubMed:9444325)
  18. Seehaus S et al. (2009) Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability. Circulation, 120:774-84. (PubMed:19687358)
  19. Werner HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J Neurosci, 27:7717-30. (PubMed:17634366)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory